287202-47-5

Upstream product

• 286459-94-7 4-but-2-ynyloxybenzenesulfonyl chloride 

Downstream Products

• 1026481-30-0 (4-but-2-ynyloxy-benzenesulfonyl)-(1-cyclopropanecarbonyl-piperidin-4-yl)-acetic acid 
• 287393-46-8 [1-(tert-butoxycarbonyl)-4-piperidinyl]{[4-(2-butynyloxy)phenyl]sulfonyl}acetic acid 
• 1026869-57-7 (4-but-2-ynyloxy-benzenesulfonyl)-(1-cyclopropanecarbonyl-piperidin-4-yl)-acetic acid ethyl ester 
• 287393-51-5 (1-benzoyl-4-piperidinyl){[4-(2-butynyloxy)phenyl]sulfonyl}acetic acid 
• 287393-50-4 ethyl (1-benzoyl-4-piperidinyl){[4-(2-butynyloxy)phenyl]sulfonyl}acetate 
• 287392-60-3 tert-butyl 4-[1-{[4-(2-butynyloxy)phenyl]sulfonyl}-2-(hydroxyamino)-2-oxoethyl]-1-piperidinecarboxylate 
• 948589-03-5 1-(tert-butyl) 3-ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1,3-piperidine dicarboxylate 
• 287201-44-9 tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-4-[(hydroxyamino)carbonyl]-1-piperidinecarboxalate 
• 287202-70-4 1-(tert-Butoxycarbonyl)-4-{[4-(2-butynyloxy)phenyl]sulfonyl}-4-piperidinecarboxylic acid 
• 287202-51-1 1-Acetyl-4-(4-but-2-ynyloxybenzenesulfonyl)piperidine-4-carboxylic acid 
• 444027-52-5 4-{[4-(2-Butynyloxy)phenyl]sulfonyl}-N-hydroxy-4-piperidinecarboxamide 
• 287202-50-0 1-acetyl-4-(4-but-2-ynyloxybenzenesulfonyl)piperidine-4-carboxylic acid methyl ester 
• 287202-49-7 4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS

Compounds of the formula:useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-α converting enzyme and matrix metalloproteinase inhibitors

A series of 4-alkynyloxy phenyl sulfanyl, sulfinyl and sulfony alkyl and piperidine-4-carboxylic acid hydroxamides were synthesized. Their structure-activity relationships, against tumor necrosis factor-α (TACE) and matrix metalloproteinase (MMP) inhibito

Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors

Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, graft rejection, cachex

Method for preparing alpha-sulfonyl hydroxamic acid derivatives

Compounds of the formula: that can be important as matrix metalloproteinase (MMP) and TNF-alpha converting enzyme (TACE) inhibitors, phosphodiesterase inhibitors, renin inhibitors, antithrombotics, and 5-lipoxygenase inhibitors are prepared by novel methods of the present invention.

An efficient method to prepare α-sulfonyl hydroxamic acid derivatives

α-Sulfonyl hydroxamic acid derivatives are biologically important molecules. An efficient protocol has been developed to make these molecules via a direct sulfonylation of enolates. Several piperidine containing α-sulfonyl hydroxamic acid compounds have been prepared by this procedure.