287399-23-9Relevant articles and documents
A stable isotope labeled 2 - isopropyl thioxanthone and its synthesis method
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Paragraph 0057; 0126-0127; 0134-0135; 0142-0143; 0226, (2018/04/21)
The invention relates to stable isotopic labeled 2-isopropylthioxanthone and a synthetic method thereof. The stable isotopic labeled 2-isopropylthioxanthone is 2-isopropylthioxanthone labeled by D or 13C. The synthetic method comprises the following steps of using benzene and acetone which are labeled by stable isotopic D or 13C as raw materials; reacting the benzene and the acetone with magnesium to obtain Grignard reagent after benzene bromination; performing reduction and hydroxide radical bromination on the acetone to obtain 2-bromic propane; performing Grignard reaction to obtain isopropyl benzene; reacting the isopropyl benzene with dithio-salicylic acid; and synthesizing to obtain the 2-isopropylthioxanthone labeled by the stable isotopic D or 13C. Compared with the prior art, the stable isotopic labeled 2-isopropylthioxanthone has the advantages that a process route is simple, the 2-isopropylthioxanthone is easy to synthesize, products are easy to separate and purify, the chemical purity of the products is above 99.0%, isotope abundance is above 98.0% atom, requirements of trace detection in the field of food safety can be met fully, and economical efficiency and using value are excellent.
Synthesis of (13C6-Ring-(U))-(±)-benzo(a) pyrene metabolites from (13C6-Ring-(U))benzene
Diel, Bruce N.,Han, Mingcheng,Kole, Panna L.,Boaz, David B.
, p. 551 - 553 (2008/02/08)
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