287403-38-7

Basic information

• Product Name: (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid
• CAS NO: 287403-38-7
• Molecular Weight: 383.489
• Mol File: 287403-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid(287403-38-7)
• EPA Substance Registry System: (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid(287403-38-7)

Safety Data

• Hazardous Substances Data: 287403-38-7(Hazardous Substances Data)

Upstream product

• 52-67-5 3,3-dimethyl-D-cysteine 
• 287407-20-9 tert-butyl 2-([4-(2-butynyloxy)phenyl]sulfonyl)amino-3-[(2hydroxyethyl)sulfanyl]-3-methylbutanoate 
• 287407-19-6 N-{[4-(2 butynyloxy)phenyl]-sulfonyl}-3-[(2-hydroxyethyl)sulfanyl]valine 
• 84915-44-6 (S)-2-Amino-3-(2-hydroxy-ethylsulfanyl)-3-methyl-butyric acid 
• 287407-94-7 4-(4-but-2-ynyloxy-benzenesulfonyl)-2,2-dimethyl-thiomorpholine-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates

The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1′ group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-α production and a collagen-induced arthritis model.