287410-55-3

Upstream product

• 211946-55-3 (R)-3-Chloromethyl-7,8-dioxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 287410-52-0 (R)-7-[1-tert-Butoxycarbonyl-meth-(Z)-ylidene]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Downstream Products

• 287410-63-3 (R)-7-[1-tert-Butoxycarbonyl-meth-(Z)-ylidene]-4-methylene-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-5,5,8-trioxo-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as β-lactamase inhibitors

A series of 2-substituted-7-(alkylidene)cephalosporin sulfones were prepared and evaluated as β-lactamase inhibitors. Compound 11c showed excellent activity as an inhibitor of the class C β-lactamase derived from Enterobacter cloacae, strain P99. (C) 2000 Elsevier Science Ltd. All rights reserved.