28744-15-2Relevant academic research and scientific papers
Synthesis, molecular docking and evaluation of library of 3-mercapto-1,2,4-triazole derivatives as antimicrobial agents
Gaonkar, Santosh L.,Hakkimane, Sushruta S.,Nayak, Swarnagowri,Shetty, Nitinkumar S.,Swapna, B.
, p. 3039 - 3046 (2021/12/14)
Due to the increasing microbial resistance to antibacterial and antifungal drugs, the development of new antimicrobial agents is an urgent priority. In search of newer antimicrobial agents, a series of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives were synthesized from aromatic acids and substituted isothiocyanates. The in silico study was performed to study the binding interactions of the synthesized compounds with the active pocket of CYP51. Among the synthesized 3-mercapto-triazole derivatives, compounds 6r, 6s and 6u exhibited promising antimicrobial activity comparable to standard drugs. The results suggested that the structural modification to 3-mercapto-1,2,4-triazole derivatives could lead to promising antimicrobial scaffolds.
Synthesis and bioactivity of some new [3-[4-methylphenoxymethyl]-4-phenyl- [1,2,4]-triazole-5-thio]acetanilide derivatives
Wei, Tai-Bao,Tang, Jing,Liu, Hong,Zhang, You-Ming
, p. 880 - 883 (2008/09/18)
The synthesis of some triazole derivatives starting from 4-methyl-phenoloxyacetyl hydrazide is described. In this process, the method for the synthesis of 2-chloroacetanilide had been improved and good yields have been obtained. The chemical structure of
