287482-35-3

Upstream product

• 131543-46-9 Glyoxal 
• 51307-68-7 N-4-chlorobenzylhydroxylamine 
• 3848-36-0 4-chlorobenzaldoxime 

Downstream Products

• 1040748-52-4 (3R,3'R)-2,2'-bis(4-chlorobenzyl)-5,5'-diphenyl-2,2',3,3'-tetrahydro-3,3'-bisisoxazole 
• 1040748-48-8 N,N'-[(R,S)-1,6-diphenylhexa-1,5-diyne-3,4-diyl]bis[N-(4-chlorobenzyl)hydroxylamine] 
• 1040748-45-5 N,N'-[(R,R)-1,6-diphenylhexa-1,5-diyne-3,4-diyl]bis[N-(4-chlorobenzyl)hydroxylamine] 

Relevant academic research and scientific papers

Catalytic asymmetric dialkynylation reaction of α-dinitrone by utilizing tartaric acid ester as a chiral auxiliary

The asymmetric addition of alkynylzinc reagents, prepared in situ from dimethylzinc and 1-alkynes, to α-dinitrones derived from glyoxal and N-(4-isopropylbenzyl)hydroxylamine was investigated by utilizing dicyclohexyl (R,R)-tartrate as a chiral auxiliary. The addition reaction of methyl(2-phenylethynyl)zinc afforded the corresponding optically active C2-symmetric (R,R)-bis(hydroxylamine) derivative with enantioselectivities of 90% and 81% ee by utilizing a stoichiometric and catalytic amount of the tartrate, respectively. Furthermore, the catalytic addition reaction of several alkynylzinc reagents also furnished the corresponding bis(hydroxylamine) with moderate to good enantioselectivities.

New NO donors with antithrombotic and vasodilating activities, Part 29. N-(1-cyanocyclohexyl)-C-phenylnitrones and glyoxaldinitrones.

Six N-(1-cyanocyclohexyl)-C-phenylnitrones 4a-f (4b-f for the first time) and 22 glyoxaldinitrones 7a-v were prepared and tested for antithrombotic (p.o. administration to rats, 60 mg/kg) effects. Both classes of compounds exhibit considerable antithrombo