2876-02-0 Hazards Identification
Pictogram(s):
Signal:
Danger
GHS Hazard Statements:
H301: Toxic if swallowed [Danger Acute toxicity, oral]
H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
Precautionary Statement Codes:
P260, P264, P270, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P405, and P501
Hazard Classes and Categories:
Acute Tox. 3 *
Skin Corr. 1B
Acute Tox. 3 (100%)
Skin Corr. 1B (100%)
Aquatic Chronic 3 (11%)
Acute toxicity - category 3
Skin corrosion - category 1A
Acute toxicity (Oral) - Category 3
Acute toxicity (Dermal) - Category 3
Skin corrosion/irritation - Category 1
Serious eye damage/eye irritation - Category 1
Carcinogenicity - Category 2
Specific target organ toxicity - Single exposure - Category 1 (central nervous system, respiratory system, cardiovascular system, liver, kidney)
Specific target organ toxicity - Repeated exposure - Category 1 (central nervous system, cardiovascular system, kidney),
Category 2 (respiratory system, blood system, liver)
Hazardous to the aquatic environment (Acute) - Category 2
Hazardous to the aquatic environment (Long-term) - Category 3
Skin corrosion/irritation - Category 1A-1C
Specific target organ toxicity - Single exposure - Category 1 (central nervous system, kidney),
Category 3 (respiratory tract irritation)
Specific target organ toxicity - Repeated exposure - Category 2 (respiratory system, central nervous system)
Carcinogens, Flammable - 2nd degree
Hazards Summary:
Causes burns; Inhalation may cause pulmonary edema; Short-term exposure may have effects on the CNS (lowering of consciousness) and blood (destruction of blood cells); Prolonged or repeated exposure may have effects on the nervous system (impaired functions) and blood (anemia); Can be absorbed through skin; [ICSC] May cause second degree skin burns after a few minutes contact; [CHRIS] The most toxic of the three cresol isomers; May cause skin sensitization; [HSDB] No evidence of skin sensitization in limited studies of humans and guinea pigs using p-cresol and m-/p-cresol; A survey reports hypersensitivity reactions of certain individuals to cresol (unspecified isomer); Neither isomer produced mortality or clinical signs of toxicity following exposure to saturated vapor concentrations, although inhalation of aerosols may be fatal; [Reference #2] Safe when used as a flavoring agent in food; [JECFA] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Highly toxic by inhalation; Toxic by ingestion and skin absorption; Targets the CNS, lungs, liver, kidney, and eyes; [Sigma-Aldrich MSDS] See Cresol, all isomers.
2876-02-0 Usage
Check Digit Verification of cas no
The CAS Registry Mumber 2876-02-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,7 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2876-02:
(6*2)+(5*8)+(4*7)+(3*6)+(2*0)+(1*2)=100
100 % 10 = 0
So 2876-02-0 is a valid CAS Registry Number.
2876-02-0Relevant academic research and scientific papers
Ortho-Selective Hydrogen Isotope Exchange of Phenols and Benzyl Alcohols by Mesoionic Carbene-Iridium Catalyst
Zhao, Liang-Liang,Wu, Yixin,Huang, Shiqing,Zhang, Zengyu,Liu, Wei,Yan, Xiaoyu
supporting information, p. 9297 - 9302 (2021/11/30)
Hydrogen isotope exchange reactions of phenols and benzyl alcohols have been achieved by a mesoionic carbene-iridium catalyst with high ortho selectivity and high functional group tolerance. Control experiments indicated that acetate is crucial to realize the ortho selectivity, whereas density functional theory calculations supported an outer-sphere direction with hydrogen bonding between acetate and the hydroxyl group.
Shifted Selectivity in Protonation Enables the Mild Deuteration of Arenes through Catalytic Amounts of Bronsted Acids in Deuterated Methanol
Fischer, Oliver,Hubert, Anja,Heinrich, Markus R.
, p. 11856 - 11866 (2020/10/23)
Taking advantage of the "differentiating effect"of the solvent methanol, deuterations of electron-rich aromatic systems can be carried out under mild acid catalysis and thus under far milder conditions than known so far. The exceptional functional group t
Catalytic Dimerization of Alkynes via C-H Bond Cleavage by a Platinum-Silylene Complex
Innocent, Jean,Kato, Tsuyoshi,Ohta, Masaya,Tobisu, Mamoru,Yoshida, Tomoki
supporting information, p. 1678 - 1682 (2020/06/08)
The cyclodimerization of diphenylacetylene derivatives catalyzed by a platinum-silylene complex is reported. The reaction proceeds via the cleavage of a carbon-hydrogen bond at the position ortho to an alkynyl group, and no additives are needed. Platinum complexes bearing other common ligands, such as phosphines and NHCs, failed to promote this reaction, highlighting the utility of the silylene ligand in this reaction.
Ipso nitration. XXII. The stereochemistry of 1,4-dimethyl-4-nitrocyclohexa-2,5-dienols and their acetates and methyl ethers
Fischer, Alfred,Henderson, George N.,Smyth, Trevor A.,Einstein, Frederick W. B.,Cobbledick, Roger E.
, p. 584 - 590 (2007/10/02)
The higher melting isomer of 1,4-dimethyl-4-nitrocyclohexa-2,5-dienol has the (E)-configuration.The stereospecific interconversion of the dienols and the corresponding acetates and the stereospecific conversion of dienols to methyl ethers allow the assign
ON THE MECHANISM OF AROMATIC HYDROXYLATION BY O(3P) ATOMS
Zadok, Elazor,Mazur, Yehuda
, p. 4955 - 4958 (2007/10/02)
It is shown that O(3P) oxidation of aromatic compounds in the liquid phase leading to phenols may involve the intermediacy of triplet diradicals
