2876-22-4

Basic information

• Product Name: phenazin-1-ylamine
• Synonyms: phenazin-1-ylamine;1-AMINOPHENAZINE;1-Phenazinamine;phenazin-1-amine;1-Aminophenazin
• CAS NO: 2876-22-4
• Molecular Formula: C₁₂H₉N₃
• Molecular Weight: 195.21996
• EINECS: 220-719-5
• Mol File: 2876-22-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 201-290 °C
• Boiling Point: 321.89°C (rough estimate)
• Flash Point: 245.4°C
• Appearance: /
• Density: 1.2142 (rough estimate)
• Vapor Pressure: 1.08E-07mmHg at 25°C
• Refractive Index: 1.6990 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.40±0.30(Predicted)
• CAS DataBase Reference: phenazin-1-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: phenazin-1-ylamine(2876-22-4)
• EPA Substance Registry System: phenazin-1-ylamine(2876-22-4)

Safety Data

• Hazardous Substances Data: 2876-22-4(Hazardous Substances Data)

Usage

Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.

InChI:InChI=1/C12H9N3/c13-8-4-3-7-11-12(8)15-10-6-2-1-5-9(10)14-11/h1-7H,13H2

Upstream product

• 3577-37-5 1-chlorophenazine 
• 56698-04-5 (2,6-dinitro-phenyl)-(2-nitro-phenyl)-amine 
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• 2538-68-3 tubermycin B 
• 54420-95-0 6-nitrodiphenylamine-2-carboxylic acid 
• 573-54-6 2-bromo-3-nitro-benzoic acid 
• 64-17-5 ethanol 
• 119-70-0 4,4'-diaminodiphenylamine-2'-sulfonic acid 
• 129-93-1 6,8-dianilino-naphthalene-1-sulfonic acid 
• 118-97-8 4-chloro-3,5-dinitrobenzoic acid 
• 95-54-5 1,2-diamino-benzene 
• 606-22-4 2,6-dinitroaniline 
• 609-73-4 o-nitroiodobenzene 
• 304-81-4 Phenazin-mono-N-Oxyd 

Downstream Products

• 528-71-2 phenazin-1-ol 

Relevant articles and documents

Studies on phenazines. VII. Nitration of phenazine and its derivatives.

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Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors

A series of novel phenazine derivatives (1~27) containing the Michael acceptor scaffolds were designed and synthesized in this study. Some compounds exhibited selective cytotoxicity against Bel-7402 cancer cell line in vitro, in which compound 26 were found to have the best antiproliferative activity. Meanwhile, compound 26 showed no obvious cell toxicity against human normal liver epithelial L02 cells, which means this compound possessed a better safety potential. In the following research, compound 26 was verified to inhibit TrxR1 enzyme activity, ultimately resulting in cellular molecular mechanism events of apoptosis including growth of intracellular ROS level, depletion of reduced Trx1, liberation of ASK1 and up-regulation of p38, respectively. Together, all these evidences implicated that compound 26 acted as the TrxR1 inhibitor against Bel-7402 cells, and could activate apoptosis through the ROS-Trx-ASK1-p38 pathway.

PHENAZINIUM MEDIATORS

The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. Moreover, the present invention relates to a method for determining the amount of an analyte in a sample, comprising contacting said sample with a chemistry matrix according to the present invention, estimating the amount of electrons liberated or consumed by the chemistry matrix in the presence of said liquid sample, and thereby determining the amount of an analyte in a liquid sample.