28769-00-8

Basic information

• Product Name: Ethyl 2,5-diiodobenzoate
• Synonyms: Ethyl 2,5-diiodobenzoate
• CAS NO: 28769-00-8
• Molecular Formula: C₉H₈I₂O₂
• Molecular Weight: 0
• Product Categories: Acids & Esters;Iodine Compounds
• Mol File: 28769-00-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 360.7°C at 760 mmHg
• Flash Point: 172°C
• Appearance: /
• Density: 2.138g/cm³
• Vapor Pressure: 2.17E-05mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: Ethyl 2,5-diiodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2,5-diiodobenzoate(28769-00-8)
• EPA Substance Registry System: Ethyl 2,5-diiodobenzoate(28769-00-8)

Safety Data

• Hazardous Substances Data: 28769-00-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8I2O2/c1-2-13-9(12)7-5-6(10)3-4-8(7)11/h3-5H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 14192-12-2 2,5-diiodobenzoic acid 
• 16170-34-6 2,5-diiodobenzoyl chloride 

Relevant articles and documents

One-Pot C-H Arylation/Lactamization Cascade Reaction of Free Benzylamines

An efficient method has been developed for the synthesis of seven-membered biaryl lactams involving Pd-catalyzed, native amine-directed, ortho-arylation of benzylamines followed by in situ lactamization. This cascade sequence is enabled by the use of 2-iodobenzoates, which facilitates C-H arylation from the free amine under conditions that typically require an improved directing group approach. This reaction is characterized by a broad substrate scope with good functional group tolerance. The need for an ester versus carboxylic acid-functionalized coupling partner is also explored, as is the potential for synthesizing eight-membered biaryl lactams. Various applications are also investigated, including access to the aza-brassinolide core.