287717-32-2

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 116119-83-6 (S)-5-hexen-1-yn-3-ol 
• 287717-31-1 tert-butyl-(1-ethynyl-but-3-enyloxy)-diphenyl-silane 

Downstream Products

• 287717-29-7 (S)-4-Benzyl-3-{(6E,8E)-(2R,3R,4S,5S,11S)-11-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-4-methyl-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-trideca-6,8-dien-12-ynoyl}-oxazolidin-2-one 
• 287717-28-6 (6E,8E)-(2R,4S,5S,11S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-11-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-4-methyl-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-trideca-6,8-dien-12-yne-1,3-dione 
• 428874-13-9 (S)-4-Benzyl-3-{(3S,4S,5R,6R)-3-[(1E,3E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-octa-1,3-dien-7-ynyl]-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl}-oxazolidin-2-one 
• 428874-37-7 (2E,4E)-(S)-7-(tert-Butyl-diphenyl-silanyloxy)-nona-2,4-dien-8-yn-1-ol 
• 287717-27-5 (2E,4E)-(S)-7-(tert-Butyl-diphenyl-silanyloxy)-nona-2,4-dien-8-ynal 
• 287717-33-3 (2E,4E)-(S)-7-(tert-Butyl-diphenyl-silanyloxy)-nona-2,4-dien-8-ynoic acid methyl ester 

Relevant academic research and scientific papers

A convergent three-component total synthesis of the powerful immunosuppressant (-)-sanglifehrin A

The potent immunosuppressive agent (-)-sanglifehrin A (5), initially discovered in a soil sample from Malawi, has been synthesized in a highly conver soil gent and stereocontrolled manner. The enantioselective approach relies on initial construction of th

Highly diastereocontrolled synthesis of the C1-C25 domain of sanglifehrin A

We report a diastereoselective synthesis of 2 containing the core structure of the entire eastern sector of sanglifehrin A. The route proceeds by directed chain extension of appropriate building blocks, their timely convergent amalgamation, and ultimate c