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287729-03-7

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  • Carbamic acid, (1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-propenyl-, 1,1-dimethylethyl ester

    Cas No: 287729-03-7

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287729-03-7 Usage

General Description

Tert-butyl allyl(1,3-dioxoisoindolin-2-yl)carbamate is a chemical compound with the formula C16H23NO4. It is a carbamate derivative that contains a tert-butyl group, an allyl group, and a 1,3-dioxoisoindolin-2-yl group. tert-butyl allyl(1,3-dioxoisoindolin-2-yl)carbaMate is often used in organic synthesis as a building block for the preparation of other carbamate derivatives. It has potential applications in the pharmaceutical industry as a precursor for the synthesis of biologically active compounds. Additionally, its unique structure makes it a valuable intermediate in the development of new materials and chemical processes. However, as with all chemical compounds, careful handling and proper safety measures should be taken when working with tert-butyl allyl(1,3-dioxoisoindolin-2-yl)carbamate.

Check Digit Verification of cas no

The CAS Registry Mumber 287729-03-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,7,2 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 287729-03:
(8*2)+(7*8)+(6*7)+(5*7)+(4*2)+(3*9)+(2*0)+(1*3)=187
187 % 10 = 7
So 287729-03-7 is a valid CAS Registry Number.

287729-03-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-(1,3-dioxoisoindol-2-yl)-N-prop-2-enylcarbamate

1.2 Other means of identification

Product number -
Other names tert-butyl allyl(1,3-dioxoisoindolin-2-yl)carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:287729-03-7 SDS

287729-03-7Upstream product

287729-03-7Relevant articles and documents

WEE1 Protein degradation agent

-

, (2021/09/21)

WEE1 Protein degradation agents are provided. , The invention provides a compound as shown V, or a pharmaceutically acceptable salt thereof, or a stereoisomer, Y-L-M thereof. WEE1 (V) Wherein M. WEE1 A WEE1 binding moiety capable of binding to WEE1 protein kinase is provided. Y Is E3 ubiquitin ligase ligand moiety, and L Is a linking group.

Development of Potent Pyrazolopyrimidinone-Based WEE1 Inhibitors with Limited Single-Agent Cytotoxicity for Cancer Therapy

Matheson, Christopher J.,Casalvieri, Kimberly A.,Backos, Donald S.,Reigan, Philip

, p. 1681 - 1694 (2018/08/01)

WEE1 kinase regulates the G2/M cell-cycle checkpoint, a critical mechanism for DNA repair in cancer cells that can confer resistance to DNA-damaging agents. We previously reported a series of pyrazolopyrimidinones based on AZD1775, a known WEE1 inhibitor, as an initial investigation into the structural requirements for WEE1 inhibition. Our lead inhibitor demonstrated WEE1 inhibition in the same nanomolar range as AZD1775, and potentiated the effects of cisplatin in medulloblastoma cells, but had reduced single-agent cytotoxicity. These results prompted the development of a more comprehensive series of WEE1 inhibitors. Herein we report a series of pyrazolopyrimidinones and identify a more potent WEE1 inhibitor than AZD1775 and additional compounds that demonstrate that WEE1 inhibition can be achieved with reduced single-agent cytotoxicity. These studies support that WEE1 inhibition can be uncoupled from the potent cytotoxic effects observed with AZD1775, and this may have important ramifications in the clinical setting where WEE1 inhibitors are used as chemosensitizers for DNA-targeted chemotherapy.

New Synthesis of 1,1-Substituted Hydrazines by Alkylation of N-Acyl- or N-alkyloxycarbonylaminophthalimide Using the Mitsunobu Protocol

Brosse, Nicolas,Pinto, Maria-Fatima,Jamart-Gregoire, Brigitte

, p. 4370 - 4374 (2007/10/03)

N-acyl- and N-alkoxycarbonylaminophthalimides are prepared using a convenient reaction and are efficiently used as acid partners in Mitsunobu reaction. This reaction allows them to be alkylated by primary, secondary or benzyl groups. Comparison of the reactivities and pKa values of these N-substituted aminophthalimides suggest that the success of the Mitsunobu reaction in this case seems to be governed more by steric than by electronic effects. A final dephthaloylation step results in an efficient method for the preparation of 1,1-substituted hydrazines.

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