28773-97-9

Basic information

• Product Name: 1,4-diacetyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
• Synonyms: 1,4-diacetyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione;1,4-Diacetyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
• CAS NO: 28773-97-9
• Molecular Formula: C₈H₁₀N₄O₄
• Molecular Weight: 226.1894
• EINECS: 249-206-4
• Mol File: 28773-97-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.481g/cm³
• Refractive Index: 1.555
• CAS DataBase Reference: 1,4-diacetyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-diacetyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione(28773-97-9)
• EPA Substance Registry System: 1,4-diacetyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione(28773-97-9)

Safety Data

• Hazardous Substances Data: 28773-97-9(Hazardous Substances Data)

Usage

Physical state

White crystalline powder

Usage

Different sources of media describe the Usage of 28773-97-9 differently. You can refer to the following data:
1. Curing agent in epoxy resins
2. Production of thermosetting plastics
3. Cross-linking agent in polymer synthesis
4. Hardener in industrial coatings

Potential application

Pharmaceutical industry (anticancer drugs)

Industrial and commercial applications

Versatile properties lead to numerous applications

InChI:InChI=1/C8H10N4O4/c1-3(13)11-6-5(9-7(11)15)10-8(16)12(6)4(2)14/h5-6H,1-2H3,(H,9,15)(H,10,16)

Upstream product

• 496-46-8 glycoluril 
• 108-24-7 acetic anhydride 
• 10543-60-9 2,4,6,8-tetraacetyl-2,4,6,8-tetraazabicyclo<3,3,0>octan-3,7-dione 

Downstream Products

• 461-72-3 2,4-imidazolidinedione 
• 55367-80-1 2-acetyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione 

Relevant articles and documents

Efficient Synthesis of Tetraacetylglycoluril in the Presence of Phosphorus-Containing Catalysts

Abstract: The effect of phosphorus-containing catalysts, namely phosphorous acid, phosphoric acid, diethyl hydrogen phosphite, and 1-hydroxyethane-1,1-diyldiphosphonic acid (HEDP), in the synthesis of tetraacetylglycoluril by acylation of glycoluril with acetic anhydride at 140°C has been studied. The use of 4 equiv of phosphorous or phosphoric acid with respect to glycoluril has been found to be the most appropriate for achieving the maximum yield (95–98%), and specific effect of HEDP leads to N-acetylation–deacetylation of substrates. The positive effect of phosphorus acids on the formation of tetraacetylglycoluril may be related to not only their catalytic action but also the ability to solubilize the substrate.

Methodes de preparation de derives nitres et nitroacetyles du glycolurile (I)

A procedure for preparing nitro and nitroacetyl derivatives of glycoluril is described, starting from tetraacetylglycoluril (TAGU).The method proceeds by nitrodeacetylation and (or) hydrolysis.New compounds have been prepared : mononitrodiacetylglycoluril (MONDAGU), dinitrodiacetylglycoluril (DINDAGU) and mononitroglycoluril (MONGU).A general synthetic scheme is proposed and discussed.Some properties of the new derivatives are presented.