287737-41-1Relevant academic research and scientific papers
Efficient Divergent Synthesis of 2′- O,4′- C-Ethylene-Bridged Nucleic Acid (ENA) Phosphoramidites
Abe, Yuzo,Ukai, Kazutoshi,Michida, Makoto
, p. 1289 - 1307 (2022/04/07)
2′-O,4′-C-Ethylene-bridged nucleic acid (ENA) phosphoramidites are highly promising modified nucleic acid monomers discovered by Daiichi Sankyo. To increase the productivity of manufacturing, we have developed a highly efficient synthetic method for ENA phosphoramidites. The basic concept of the new synthetic route is "divergent synthesis"for the preparation of four types of monomers such as A, G, C, and T. We applied stereoselective glycosylation reactions without utilizing neighboring group participation to set a common intermediate in the downstream of the route.
An improved synthesis of 2′-O,4′-C-ethylene nucleic acid (ENA) and thermodynamic studies of duplex formation containing the guanosine ENA unit
Takagi-Sato, Miho,Morita, Koji,Onishi, Yoshiyuki,Watahiki, Yuuka,Ishigaki, Taku,Akita, Tomoka,Tomita, Erisa,Kawakami, Junji,Koizumi, Makoto
, p. 838 - 852 (2020/02/13)
Oligonucleotides containing 2′-O,4′-C-ethylene nucleic acids (ENA) have been proven highly effective for antisense therapeutics. 2′-O,4′-C-Ethyleneguanosine and its phosphoramidite were previously obtained from 3,5-di-O-benzy1-4-C-(p-tolulenesulfonyloxyet
Synthesis and properties of 2′-O,4′-C-ethylene-bridged nucleic acids (ENA) as effective antisense oligonucleotides
Morita, Koji,Takagi, Miho,Hasegawa, Chikako,Kaneko, Masakatsu,Tsutsumi, Shinya,Sone, Junko,Ishikawa, Tomio,Imanishi, Takeshi,Koizumi, Makoto
, p. 2211 - 2226 (2007/10/03)
Novel bicyclo nucleosides, 2′-O,4′-C-ethylene nucleosides and 2′-O,4′-C-propylene nucleosides, were synthesized as building blocks for antisense oligonucleotides to further optimize the 2′-O,4′-C-methylene-linkage of bridged nucleic acids (2′,4′-BNA) or l
