287737-52-4Relevant academic research and scientific papers
Synthesis and properties of 2′-O,4′-C-ethylene-bridged nucleic acids (ENA) as effective antisense oligonucleotides
Morita, Koji,Takagi, Miho,Hasegawa, Chikako,Kaneko, Masakatsu,Tsutsumi, Shinya,Sone, Junko,Ishikawa, Tomio,Imanishi, Takeshi,Koizumi, Makoto
, p. 2211 - 2226 (2007/10/03)
Novel bicyclo nucleosides, 2′-O,4′-C-ethylene nucleosides and 2′-O,4′-C-propylene nucleosides, were synthesized as building blocks for antisense oligonucleotides to further optimize the 2′-O,4′-C-methylene-linkage of bridged nucleic acids (2′,4′-BNA) or l
