2878-60-6

Upstream product

• 501-52-0 3-Phenylpropionic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 621-82-9 Cinnamic acid 
• 56361-03-6 N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylacrylamide 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 1430088-67-7 styelsamine-N¹⁴-3-phenylpropanamide 
• 1430088-71-3 cystodytin-N¹⁴-3-phenylpropanamide 
• 1430088-76-8 O-methyl styelsamine-N¹⁴-2-phenylacetamide 
• 1430088-78-0 O-methyl styelsamine-N¹⁴-3-phenylpropanamide 
• 29903-68-2 (+/-)-6,7-dimethoxy-1-[2-(phenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline 
• 81305-67-1 3,4-dihydro-6,7-dimethoxy-1-(2-phenylethyl)isoquinoline 

Relevant academic research and scientific papers

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Biomimetic Total Synthesis of Dysoxylum Alkaloids

A five-step total synthesis of Dysoxylum alkaloids has been achieved using a biomimetic approach from zanthoxylamide protoalkaloids. The synthesis featured a direct amidation and a Bischler-Napieralski reaction to form the dihydroisoquinoline ring, which

Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors

We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step for the

Synthesis, DNA binding and antitumor evaluation of styelsamine and cystodytin analogues

A series of N-14 sidechain substituted analogues of styelsamine (pyrido[4,3,2-mn]acridine) and cystodytin (pyrido[4,3,2-mn]acridin-4-one) alkaloids have been prepared and evaluated for their DNA binding affinity and antiproliferative activity towards a pa