28791-26-6

Basic information

• Product Name: m-nitro-N-phenylbenzenesulphonamide
• Synonyms: m-nitro-N-phenylbenzenesulphonamide;3-Nitro-N-phenylbenzenesulfonamide;3-NITROBENZENESULFONANILIDE 3-NITRO-N-PHENYLBENZENESULFONAMIDE;m-Nitrobenzenesulfonanilide;N-Phenyl-3-nitrobenzenesulfonamide
• CAS NO: 28791-26-6
• Molecular Formula: C₁₂H₁₀N₂O₄S
• Molecular Weight: 278.2838
• EINECS: 249-225-8
• Mol File: 28791-26-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 122-123 °C
• Boiling Point: 454.2 °C at 760 mmHg
• Flash Point: 228.5 °C
• Appearance: /
• Density: 1.461 g/cm³
• Vapor Pressure: 1.94E-08mmHg at 25°C
• Refractive Index: 1.656
• PKA: 7.88±0.30(Predicted)
• CAS DataBase Reference: m-nitro-N-phenylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: m-nitro-N-phenylbenzenesulphonamide(28791-26-6)
• EPA Substance Registry System: m-nitro-N-phenylbenzenesulphonamide(28791-26-6)

Safety Data

• Hazardous Substances Data: 28791-26-6(Hazardous Substances Data)

Usage

General Description

M-nitro-N-phenylbenzenesulphonamide, also known as N-(3-nitrophenyl)benzenesulfonamide, is a chemical compound with the molecular formula C12H10N2O4S. It is a member of the benzenesulfonamide family and is commonly used in the synthesis of pharmaceuticals and organic chemicals. This chemical is a yellow crystalline solid at room temperature and has a variety of industrial and research applications. It is typically used as an intermediate in the production of dyes, pharmaceuticals, and agrochemicals due to its ability to act as a precursor for a range of more complex compounds. While it has several industrial uses, m-nitro-N-phenylbenzenesulphonamide should be handled with care due to its potential for causing skin and eye irritation, as well as being harmful if ingested or inhaled.

InChI:InChI=1/C12H10N2O4S/c15-14(16)11-7-4-8-12(9-11)19(17,18)13-10-5-2-1-3-6-10/h1-9,13H

Upstream product

• 7664-93-9 sulfuric acid 
• 62-53-3 aniline 
• 6647-85-4 3-nitrobenzenesulfonyl azide 
• 71-43-2 benzene 
• 121-51-7 3-nitrobenzenesulphonyl chloride 

Downstream Products

• 80-21-7 1-aminobenzene-3-sulphonic acid phenylamide 
• 108368-76-9 3-nitro-benzenesulfonic acid-[N-(2-hydroxy-ethyl)-anilide] 
• 16340-08-2 N-(Trichlormethyl-dithio)-m-nitro-benzolsulfonsaeure-anilid 

Relevant articles and documents

Cardiosulfa, a small molecule that induces abnormal heart development in zebrafish, and its biological implications

A change of heart: Cardiosulfa, a small molecule that induces heart deformation during zebrafish development, has been identified by using a forward chemicalgenetic approach. Zebrafish embryos exposed to cardiosulfa have a narrow and elongated heart within an enlarged pericardial sac (see picture; heart marked with green fluorescent protein).

2-Anilino-4-(Heterocyclic) Amino-Pyrimidines

The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-α). The PKC-α inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

Antifungal activities of N-arylbenzenesulfonamides against phytopathogens and control efficacy on wheat leaf rust and cabbage club root diseases.

A set of N-arylbenzenesulfonamides with various substituents at the arylamine and benzenesulfonyl positions were prepared, and their antifungal properties were measured in vitro against such plant pathogenic fungi as Pythium ultimum, Phytophthora capsici, Rhizoctonia solani, and Botrytis cinerea. Compounds 3, 4, 8, 9, 10, 14, 16, 18, 20, 21, 24 and 27 had antifungal activity over a broad spectrum of the phytopathogenic fungi tested, where 50% of inhibition (ED50) was in the range of 3-15 microg/ml. Based on the in vitro activity, six derivatives (3, 4, 10, 18, 21 and 27) were selected and tested further for their fungicidal efficacy in vivo. The fungicidal efficacy of 10, 21 and 27 had a disease control value of over 85% at 50 microg/ml against wheat leaf rust, while that of 4 was selective against cabbage club root disease.