28791-95-9

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1-Ethoxyethyl)-1H-pyrazole is utilized as an intermediate in the production of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agricultural Chemicals:
1-(1-Ethoxyethyl)-1H-pyrazole also serves as an intermediate in the synthesis of agricultural chemicals, playing a role in the production of pesticides, herbicides, and other agrochemicals that are essential for maintaining crop health and productivity.
Used in Corrosion Inhibition:
1-(1-Ethoxyethyl)-1H-pyrazole has been investigated for its potential application as a corrosion inhibitor in metal surface treatments. Its ability to protect metals from corrosion makes it a valuable candidate for use in industrial processes where metal preservation is crucial.

Upstream product

• 288-13-1 NH-pyrazole 
• 109-92-2 ethyl vinyl ether 
• 575452-22-1 1-(1-ethoxyethyl)-4-iodo-1H-pyrazole 
• 575452-26-5 1-(1-ethoxyethyl)-4-ethynyl-1H-pyrazole 

Relevant academic research and scientific papers

Ethyl vinyl ether - An agent for protection of the pyrazole NH-fragment. A convenient method for the preparation of N-unsubstituted 4-alkynylpyrazoles

N-Unsubstituted 4-iodopyrazole (1) is easily converted into 4-alkynyl derivatives (5) in moderate to good overall yields by using intermediate protection of the nitrogen atom of the pyrazole ring by ethyl vinyl ether.

Synthesis of substituted-3-iodo-1H-pyrazole derivatives and their further modification under Sonogashira cross-coupling reaction conditions

A convenient synthetic route for preparation of valuable synthetic intermediates - 1-(1-ethoxyethyl)-3-iodo-1H-pyrazole derivatives has been developed. During this work protection reaction of N-H bond in substituted 3-iodo-1H-pyrazole derivatives with ethyl vinyl ether and migration of ethoxyethyl protecting group was investigated. Synthetic possibilities of Sonogashira cross-coupling reactions of substituted 1-(1-ethoxyethyl)-3-iodo-1H-pyrazole derivatives with phenylacetylene were studied and evaluated.