287919-83-9Relevant academic research and scientific papers
Convenient synthesis of 2,9-disubstituted guanines mediated by solid- supported reagents
McComas, Warren,Chen, Li,Kim, Kyungjin
, p. 3573 - 3576 (2000)
A novel application has been developed to separate regioisomers chemoselectively using a solid-supported reagent. An N7/N9 purine regioisomer mixture was purified using aluminum oxide/H+ to provide the N9 isomer selectively as a parallel or high-throughput format (chemoselective high- throughput purification). 2,9-Disubstituted guanines were conveniently prepared by this new method in conjunction with solid-supported reagents. (C) 2000 Elsevier Science Ltd.
