287925-06-8Relevant articles and documents
N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
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Page column 17, (2008/06/13)
Low-toxicity, highly-bioavailable, pharmaceutical antioxidant compositions for preferred oral administration to mammals are provided which have at least one amino acid-based compound of the general formula (I): A—N(Z)—CH(R1)C(O)—Q??(I) wherein A is represented by the formula: XO—[C(R2)2]n— wherein n is an integer of from 1 to about 3, X is selected from the group consisting of a hydrogen atom, an acyl group and a halogenated acyl group and each R2is independently selected from the group consisting of a hydrogen atom, an alkyl group having from 1 to about 3 carbon atoms, a hydroxyalkyl group having from 1 to about 3 carbon atoms, and CH2OX; Z is selected from the group consisting of a hydrogen atom, an alkyl group of from 1 to about 3 carbon atoms, and A; R1is an amino acid side chain group or an amino acid side chain group which forms with R2a single heterocyclic structure having a total of from 5 to 7 atoms in the ring; and wherein Q is a substituent selected from the group consisting of a hydroxyl, —N(R2)2, —NR2(NR2)2, —SR2, an alkoxy, a halogenated alkoxy, an O-acyl and an O-halogenated acyl are disclosed. Methods of treating, delaying the onset of and/or preventing antioxidant responsive diseases comprising administering such pharmaceutical antioxidant compositions and amino acid-based compounds of the general formula (I) are also disclosed.
