287928-06-7

Upstream product

• 107-19-7 propargyl alcohol 
• 2904-62-3 2,6-dichlorobenzonitrile N-oxide 
• 6575-28-6 (1E)-2,6-dichlorobenzaldehyde oxime 

Downstream Products

• 908848-64-6 methanesulfonic acid 3-(2,6-dichloro-phenyl)-isoxazol-5-ylmethyl ester 
• 919285-71-5 {4-[3-(2,6-dichloro-phenyl)-isoxazol-5-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester 

Relevant academic research and scientific papers

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.

AZABICYCLONONENE DERIVATIVES AS RENIN INHIBITORS

The invention relates to novel bicyclononene derivatives, related compounds and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the