287930-11-4Relevant academic research and scientific papers
First example of a total axial to centered chirality transfer in the [2+2+2] cycloadditions of allenediynes
Buisine, Olivier,Aubert, Corinne,Malacria, Max
, p. 985 - 989 (2000)
The cobalt-mediated [2+2+2] cycloaddition of allenediynes bearing a phosphine oxide group at one alkyne terminus is a completely regio-, chemo- and diastereoselective high yielding process. Moreover, a total transfer of chiral information from axial to centered chirality is evident, which makes this reaction a new and powerful tool for the preparation of enantiomerically enriched tricyclic derivatives.
