287943-34-4Relevant academic research and scientific papers
Direct ortho-palladation of 2-phenyl-2-oxazoline: Crystal structure of Cl2Pd(OCH2CH2N=C-Ph)2 and Cl(PPh3)Pd(OCH2CH2N=C-C6H 4)
Smoliakova, Irina P.,Keuseman, Kristopher J.,Haagenson, Dana C.,Wellmann, Dawn M.,Colligan, Peter B.,Kataeva, Nadezhda A.,Churakov, Andrey V.,Kuz'mina, Lyudmila G.,Dunina, Valery V.
, p. 86 - 97 (2000)
Direct ortho-palladation of sterically non-hindered 2-phenyl-2-oxazoline (1) using Pd(OAc)2 and AcONa in AcOH provided di-μ-acetatobis-[2-(2-oxazolinyl)phenyl,1-C,3-N]dipalladium(II) (3a) in a yield of 63%. Dimeric complex 3a was converted into
Solvent-free cyclopalladation on silica gel
Smoliakova, Irina P.,Wood, Jessica L.,Stepanova, Valeria A.,Mawo, Relindis Y.
, p. 360 - 364 (2010/05/01)
Tertiary, secondary and primary benzylamines, as well as structurally different oxazolines readily reacted with Pd(OAc)2 on silica gel to form cyclopalladated complexes containing a five or six-membered palladacycle with a (sp2)C-Pd or (sp3)C-Pd bond. The complexes were obtained in 45-98% yield, which is comparable with or exceeds the yields reported for preparation of the same compounds in solution. Aliphatic (sp3)C-H bond activation took place in the cyclopalladation of (S)-2-tert-butyl-4-phenyl-2-oxazoline on SiO2 leading to the exclusive formation of the corresponding endo palladacycle, whereas two products were reported for the same reaction performed in AcOH.
