28795-07-5

Upstream product

• 21269-61-4 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one 

Downstream Products

• 1384426-48-5 N-(3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)butyramide 
• 620545-50-8 2-chloro-N-(3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide 
• 620545-14-4 N-(3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)benzamide 
• 1384426-50-9 N-(3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acrylamide 
• 1384426-49-6 2,2,2-trichloro-N-(3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide 
• 620545-34-8 N-(3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)acetamide 
• 28795-10-0 3,6,6-trimethyl-1-phenyl-6,7-dihydro-1H-indazole 

Relevant academic research and scientific papers

A facile synthesis of 4-acylamino-tetrahydroindazoles via the Ritter reaction

A new route toward 4-acylamino- and 4-amino-substituted tetrahydroindazoles is disclosed. The title compounds are obtained in good to excellent yields in the Ritter reaction between 4-hydroxy-tetrahydroindazoles and various nitriles. The reactivity of the tetrahydroindazole-derived carbenium ion is both sufficiently high to react with trichloroacetonitrile and sufficiently selective to resist the azide functionality within its structure. The present approach adds a method to the toolbox of tetrahydroindazole chemistry and facilitates the structural modifications of the scaffold, which has found important applications in medicinal chemistry.