287974-12-3

Basic information

• Product Name: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-,(8aS)-(9CI)
• Synonyms: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-,(8aS)-(9CI)
• CAS NO: 287974-12-3
• Molecular Formula: C8H11NO
• Molecular Weight: 0
• Product Categories: AMINETERTIARY
• Mol File: 287974-12-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-,(8aS)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-,(8aS)-(9CI)(287974-12-3)
• EPA Substance Registry System: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-,(8aS)-(9CI)(287974-12-3)

Safety Data

• Hazardous Substances Data: 287974-12-3(Hazardous Substances Data)

Upstream product

• 82259-09-4 (5S)-(+)-5-(1-Prop-2-enyl)-2-pyrrolidinone 
• 1378306-68-3 (S)-methyl 4-((S)-1,1-dimethylethylsulfinamido)hept-6-enoate 
• 287974-07-6 (S)-5-Allyl-1-((S)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-one 
• 287974-10-1 (S)-1,5-diallylpyrrolidin-2-one 

Downstream Products

• 142796-65-4 (8aR)-perhydro-3-indolizidinone 

Relevant articles and documents

A versatile enantioselective synthesis of azabicyclic ring systems: A concise total synthesis of (+)-grandisine D and unnatural analogues

Closing in on azacines: We have developed a new six step approach for the rapid and enantioselective synthesis of indolizidine, pyrrolo[1,2-a]azepine, and pyrrolo[1,2-a]azocine azabicyclic systems and their respective lactam congeners, which are found in a host of natural products as well as pharmaceutical preparations. This protocol enables a concise enantioselective total synthesis of (+)-grandisine D in 16.4 % overall yield from commercial materials (see scheme). Copyright