287974-12-3

Upstream product

• 287974-10-1 (S)-1,5-diallylpyrrolidin-2-one 
• 1378306-68-3 (S)-methyl 4-((S)-1,1-dimethylethylsulfinamido)hept-6-enoate 
• 287974-07-6 (S)-5-Allyl-1-((S)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-one 
• 82259-09-4 (5S)-(+)-5-(1-Prop-2-enyl)-2-pyrrolidinone 

Downstream Products

• 142796-65-4 (8aR)-perhydro-3-indolizidinone 

Relevant academic research and scientific papers

A versatile enantioselective synthesis of azabicyclic ring systems: A concise total synthesis of (+)-grandisine D and unnatural analogues

Closing in on azacines: We have developed a new six step approach for the rapid and enantioselective synthesis of indolizidine, pyrrolo[1,2-a]azepine, and pyrrolo[1,2-a]azocine azabicyclic systems and their respective lactam congeners, which are found in a host of natural products as well as pharmaceutical preparations. This protocol enables a concise enantioselective total synthesis of (+)-grandisine D in 16.4 % overall yield from commercial materials (see scheme). Copyright

Concise synthesis of indolizidines: Total synthesis of (-)-coniceine

The Ti-mediated allylsilane addition to bicyclic lactams occurs with high stereoselectivity and combined with a ring closure metathesis provides the title compounds in high ee.