288-37-9

Usage

Uses

Used in Pharmaceutical Industry:
1,2,5-Oxadiazole is used as a potent inhibitor for indoleamine 2,3-dioxygenase, which is useful for the treatment of cancer and other disorders. It is also useful as a new class of SENP2 inhibitors and can be used for the development of novel therapeutic agents for various diseases targeting SENPs.
Used in Biological Studies:
1,2,5-Oxadiazole-2-oxides are used as a source of NO (Nitric Oxide) in biological studies, which can be beneficial for understanding various biological processes and mechanisms.
Used in Cardiovascular Research:
4-Amino-1,2,5-oxadiazole-2-oxide-3-carboxylic acid and azo derivatives have been studied for their vasodilating properties, which can be useful in the development of treatments for cardiovascular diseases.

InChI:InChI=1/C2H2N2O/c1-2-4-5-3-1/h1-2H

Upstream product

• 557-30-2 glyoxime 
• 34587-59-2 hexane-2,3,5-trione trioxime 
• 64-17-5 ethanol 

Downstream Products

• 127219-89-0 Furazan-3-yl-acetic acid methyl ester 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 88097-21-6 3,4-diphenylfurazan-3',3''-disulphonyl dichloride 

Relevant academic research and scientific papers

Trisubstituted heterocyclic compounds and their use as fungicides

Compounds of general formula (I): in which:Het represents a five or six membered saturated, partially unsaturated or aromatic ring containing between one and six heteroatoms of the group N, O, S, in which the heterocycle is substituted in an adjacent manner with -P-Q1-T-Q2, -GZ and Y, such that the substituant -GZ is adjacent to both. the other substituants being as defined in the description,process for preparing these compounds,fungicidal compositions comprising these compounds,processes for treating plants by applying these compounds or compositions.

Substituted amino methyl factor Xa inhibitors

The present application describes substituted-aminomethyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

Heteroaryl-phenyl substituted factor Xa inhibitors

The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of factor Xa.

Heteroaryl- phenyl heterobicyclic factor Xa inhibitors

The present application describes heteroaryl-phenyl heterobicycles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa

The present application describes inhibitors of factor Xa of formula I: or pharmaceutically acceptable salt forms thereof, wherein W, W1, W2, and W3may be N or C and J, Ja, and Jbcombine to form a substituted carbocycle or heterocycle.

6-membered aromatics as factor Xa inhibitors

The present application describes 6-membered aromatics of formula I: or pharmaceutically acceptable salt forms thereof, wherein D may be CH2NH2 or C(=NH)NH2, which are useful as inhibitors of factor Xa.

N-(AMIDINOPHENYL) CYCLOUREA ANALOGS AS FACTOR XA INHIBITORS

The present application describes N-(amidinophenyl)cyclourea analogs of formula I: STR1 which are useful as inhibitors of factor Xa.

INHIBITORS OF FACTOR XA WITH A NEUTRAL P1 SPECIFICITY GROUP

The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: STR1 or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.

α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors

The present application describes m-amidino phenyl analogs of formula I: wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.

Benzo-fused cyclic compounds

Herbicidal benzo-fused cyclic compounds of the formula STR1 wherein Q is STR2 Y is O or S, W is STR3 T is O, S, --NH-- or STR4 and R4 may represent, together with T, chlorine, Z is O or S, X is hydrogen or halogen, n is 0 or 1 and R is C3-6 cycloalkyl, an optionally substituted 5-membered heterocyclic group or an optionally substituted 6-membered heteroaromatic group which contains one to three nitrogen atoms, and salts thereof.