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288-42-6

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288-42-6 Usage

Description

Oxazole is the primary compound for a various class of heterocyclic aromatic organic compounds, which include azoles with a nitrogen and an oxygen separated by one carbon. Oxazole is a weak base and an aromatic compound.

Preparation

There are various methods of synthesizing oxazole in organic chemistry including Van Leusen reaction with TosMIC and aldehydes, Robinson-Gabriel preparation by dehydration of 2-acylaminoketones, and Bredereck reaction with formamide. Oxazole result from the oxidation and cyclization of threonine and serine non-ribosomal peptides.

Chemical Properties

Colorlesstolightyellowliqui

Uses

Oxazole and its derivatives are actively involved as building blocks for bio chemicals and pharmaceuticals like flopristin and darglitazone. It is also involved in industrial applications such as in dyes, fluorescent brightening agents, textile auxiliaries and plastics.

Definition

Different sources of media describe the Definition of 288-42-6 differently. You can refer to the following data:
1. ChEBI: A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.
2. oxazole: A heterocyclic compoundhaving a nitrogen atom and an oxygenatom in a five-membered ring,C3H3NO.

General Description

Oxazole ring is present in various natural products. The diradical interactions in the ring-opening reaction of oxazole were studied.

Check Digit Verification of cas no

The CAS Registry Mumber 288-42-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,8 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 288-42:
(5*2)+(4*8)+(3*8)+(2*4)+(1*2)=76
76 % 10 = 6
So 288-42-6 is a valid CAS Registry Number.
InChI:InChI=1/C3H3NO/c1-2-5-3-4-1/h1-3H

288-42-6 Well-known Company Product Price

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  • Alfa Aesar

  • (L18341)  Oxazole, 98+%   

  • 288-42-6

  • 1g

  • 856.0CNY

  • Detail
  • Alfa Aesar

  • (L18341)  Oxazole, 98+%   

  • 288-42-6

  • 5g

  • 3820.0CNY

  • Detail
  • Aldrich

  • (230138)  Oxazole  98%

  • 288-42-6

  • 230138-1G

  • 998.01CNY

  • Detail
  • Aldrich

  • (230138)  Oxazole  98%

  • 288-42-6

  • 230138-10G

  • 4,550.13CNY

  • Detail

288-42-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-oxazole

1.2 Other means of identification

Product number -
Other names OXAZOLE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:288-42-6 SDS

288-42-6Relevant articles and documents

Gold(I)-catalyzed protodecarboxylation of (Hetero)aromatic carboxylic acids

Dupuy, Stéphanie,Nolan, Steven P.

supporting information, p. 14034 - 14038 (2013/11/19)

Readily available, inexpensive and easy to handle, carboxylic acids have been shown to be very effective, greener coupling partners compared to costly organometallic reagents for the formation of C-C bonds. The use of well-defined gold complexes furnished 3 in slightly better yield with butyric acid, and in quantitative yield with adamantane-1-carboxylic acid. All reactions reached completion within 16 h. As with silver systems, this reactivity trend highlights, as previously observed, the benefits of potential coordinating groups in the ortho position to the gold binding site, which possibly facilitate the decarboxylation step. Additional reaction time and increased temperatures were necessary to afford the gold aryl products in satisfactory yields. Yet, some substrates such as 2-nitrobenzoic acids reacted poorly and could only be transformed in 50% yield.

Reactivity of neutral nitrogen donors in square-planar d8 metal complexes: The system chloro(2,2′:6′,2″-terpyridine)platinum(II) cation with five-membered N-donor heterocycles in methanol

Pitteri, Bruno,Bortoluzzi, Marco

, p. 2698 - 2704 (2008/10/09)

The kinetics of the forward and reverse steps of the reaction [Pt(terpy)Cl]+ + nu ? [Pt(terpy)(nu)]2+ + Cl- (terpy = 2,2′:6′,2″-terpyridine, nu = one of a number of thiazoles, oxazole, isoxazole, imidazole, pyrazole and 3,5-dimethylpyrazole, covering a wide range of basicities) have been studied in methanol at 25 °C. Both forward and reverse reactions obey the usual two-term rate law observed in square-planar substitution. The second-order rate constants for the forward reactions, k2f, show a slight dependence upon the basicity of the entering nu, while the steric hindrance due to the presence of one methyl group in the α position to the nitrogen markedly decreases the reactivity. The second-order rate constants for the reverse reactions, k2r, are very sensitive to the nature of the leaving group and a plot of log k2r against the pKa of the conjugate acids of the unhindered five-membered N-donors is linear with a slope of -0.51. The results are compared with data from the literature regarding a series of pyridines reacting with the [Pt(terpy)Cl]+ cation under the same experimental conditions. Both in the forward and in the reverse reaction, the reactivity depends not only upon the ligand basicity but also upon the nature of the nucleophile in the order: (thiazoles, oxazole, isoxazole, imidazole, pyrazoles) > pyridines for the entry of N-donors and on the contrary for the displacement by Cl-. Steric retardation, due to the presence of a methyl group in the α position to the nitrogen, is remarkably lower for five-membered N-donors if compared to pyridines both in the forward and in the reverse reaction.

Fatty acid synthase inhibitors

-

, (2008/06/13)

This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.

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