2880-91-3

Usage

Uses

Used in Pharmaceutical Research:
Uridine, 5-iodo-, 2',3',5'-tribenzoate is utilized as a research compound for exploring its potential as a therapeutic agent. Its unique structure, which includes the iodine atom and benzoate groups, is hypothesized to offer advantages in terms of stability and interaction with biological targets, making it a promising candidate for the development of new drugs.
Used in Neurological Disorder Treatment:
In the field of neurology, Uridine, 5-iodo-, 2',3',5'-tribenzoate is used as a potential therapeutic agent for neurological disorders. Uridine, 5-iodo-, 2',3',5'-tribenzoate's effects on neurotransmitter systems and brain function suggest that it could play a role in the treatment or management of such conditions, although further research is necessary to validate these possibilities.
Used in Cognitive Enhancement Research:
Uridine, 5-iodo-, 2',3',5'-tribenzoate is also being investigated for its potential to enhance cognitive function. Given the importance of uridine in the synthesis of RNA and its role in brain health, this derivative may offer insights into improving cognitive abilities or treating cognitive decline associated with certain conditions.
Used in Drug Development:
In the pharmaceutical industry, Uridine, 5-iodo-, 2',3',5'-tribenzoate serves as a key compound in the development of novel drugs. Its unique properties and potential interactions with biological targets make it a valuable asset in the quest to create new treatments for a variety of diseases, particularly those affecting the nervous system.

Upstream product

• 1748-04-5 tribenzoyl uridine 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 38953-72-9 5-iodo-2,4-bis-O-trimethylsilyluracil 
• 613-90-1 benzoyl cyanide 
• 1024-99-3 5-iodouridine 

Downstream Products

• 1748-04-5 tribenzoyl uridine 
• 1109220-19-0 2',3',5'-tri-O-benzoyl-5-deuterouridine 
• 1024-99-3 5-iodouridine 
• 1372629-16-7 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-iodo-4-(1,2,4-triazol-1-yl)pyrimidin-2(1H)-one 
• 1372629-21-4 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-(propyn-1-yl)-4-(1,2,4-triazol-1-yl)pyrimidin-2(3H)-one 
• 1372629-28-1 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-(trimethylsilylethynyl)-4-(1,2,4-triazol-1-yl)pyrimidin-2(3H)-one 
• 1372629-19-0 2',3',5'-tri-O-benzoyl-5-(propyn-1-yl)uridine 
• 1372629-20-3 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-6-methylthieno[2,3-d]pyrimidin-2(3H)-one 
• 2880-93-5 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-iodo-4-methoxypyrimidin-2(1H)-one 
• 136112-90-8 4-(1,2,4-triazol-1-yl)-1-(β-D-2,3,5-tri-O-benzoylribofuranosyl)pyrimidine-2(1H)-one 
• 1372629-10-1 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-6-methylfuro[2,3-d]pyrimidin-2(3H)-one 
• 69075-41-8 2',3',5'-tri-O-benzoyl-5-ethynyluridine 
• 935753-52-9 2',3',5'-tri-O-benzoyl-5-iodo-3-methyluridine 
• 140424-81-3 2',3',5'-tri-O-benzoyl-5-(trimethylsilylethynyl)uridine 

Relevant academic research and scientific papers

Inhibition of tyrosyl-DNA phosphodiesterase 1 by lipophilic pyrimidine nucleosides

Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose) polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2′,3′,5′-tri-O-benzoyl-d-ribofuranose and 5-substituted uracil moieties and have half-maximal inhibitory concentrations (IC50) in the lower micromolar and submicromolar range. 2′,3′,5′-Tri-Obenzoyl- 5-iodouridinemanifested the strongest inhibitory effect on Tdp1 (IC50 = 0.6 μM). Adecrease in the number of benzoic acid residues led to a marked decline in the inhibitory activity, and pyrimidine nucleosides lacking lipophilic groups (uridine, 5-fluorouridine, 5-chlorouridine, 5-bromouridine, 5-iodouridine, and ribothymidine) did not cause noticeable inhibition of Tdp1 (IC50 > 50 μM). No PARP1/2 inhibitors were found among the studied compounds (residual activity in the presence of 1mMsubstances was 50-100%). Several O-benzoylated uridine and cytidine derivatives strengthened the action of topotecan on HeLa cervical cancer cells.

A solid-supported acidic oxazolium perchlorate as an easy-handling catalyst for the synthesis of modified pyrimidine nucleosides via Vorbrüggen-type N-glycosylation

A solid-supported acidic oxazolium perchlorate was investigated as a heterogeneous catalyst in N-glycosylation reactions using silylated modified pyrimidines and an acylated ribose or glucose to afford the corresponding pyrimidine nucleosides. This salt is a nonhygroscopic and stable powder whose activity is comparable to that of 2-methyl-5-phenylbenzoxazolium perchlorate. A reaction with this polymer catalyst can be conducted on a gram scale. Reusability of the solid-supported catalyst was also investigated.

Synthesis of modified pyrimidine nucleosides via Vorbrüggen-type N-glycosylation catalyzed by 2-methyl-5-phenylbenzoxazolium perchlorate

Several acidic azolium salts prepared from oxazole, thiazole, and imidazole derivatives were investigated as catalysts in N-glycosylation reaction using a silylated modified pyrimidine and an acylated ribose or glucose to afford the corresponding pyrimidine nucleoside. Among the salts, 2-methyl-5- phenylbenzoxazolium perchlorate showed the highest catalytic activity. This salt is a nonhygroscopic crystalline compound that shows higher activity than the frequently used trimethylsilyl triflate. Reactions with this salt can be conducted in gram scales.

One-flow, multistep synthesis of nucleosides by Bronsted acid-catalyzed glycosylation

Nucleosides in flow: A general, scalable method of Bronsted acid-catalyzed nucleoside formation is described. Because of the high reaction temperatures readily available to the flow reaction format, mild Bronsted acids, particularly pyridinium triflates, can be used. A one-flow multistep synthesis of unprotected nucleosides is also reported (see scheme).

Iodination with Silver Sulfate and Iodine. II. Uridines

Iodination of uridines with iodine and silver sulfate at room temperature gives iodinated uridines in excellent yield.