288088-63-1Relevant academic research and scientific papers
Synthesis of a potent aminocyclitol α-mannosidase inhibitor, 1L-(1,2,3,5/4)-5-amino-4-O-methyl-1,2,3,4-cyclopentanetetrol
Ogawa, Seiichiro,Morikawa, Takayuki
, p. 1047 - 1050 (2007/10/03)
Demethylthio-, de-S-methyl-, and ethylthio-derivatives of the α-mannosidase inhibitor, mannostatin A, have been synthesized and evaluated for their inhibition of Jack bean α-mannosidase in order to elucidate the roles of the methylthio group. All derivati
Preparation of optically active derivatives of (1,4/2,3,5)- and (1,2,3,4,5/0)-5-aminocyclopentane-1,2,3,4-tetraols: synthesis of mannostatin A and its enantiomer
Ogawa, Seiichiro,Kimura, Hiroshi,Uchida, Chikara,Ohashi, Takashi
, p. 1695 - 1706 (2007/10/02)
Diastereoselective acylation of the 2,3-O-cyclohexanediyl derivatives of (1,4/2,3,5)- and (1,2,3,4,5/0)-5-acetamidocyclopentane-1,2,3,4-tetraols with some optically active chiral acids afforded, with moderate diastereoselectivity, the chiral monoesters useful as synthetic intermediates, from which mannostatin A and its enantiomer were synthesized.
