2881-31-4

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-OXO-2-PHENYLETHYL)BENZOIC ACID is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical structure and ability to inhibit the activity of the enzyme dipeptidyl peptidase-4. This makes it a valuable component in the development of drugs targeting blood sugar regulation and other therapeutic applications.
Used in Agrochemical Industry:
2-(2-OXO-2-PHENYLETHYL)BENZOIC ACID is used as a building block for the preparation of various agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Synthesis:
2-(2-OXO-2-PHENYLETHYL)BENZOIC ACID is used as a key intermediate in organic synthesis, allowing for the creation of a wide range of chemical compounds with diverse applications.
Used in Enzyme Inhibition:
2-(2-OXO-2-PHENYLETHYL)BENZOIC ACID is used as an inhibitor of the enzyme dipeptidyl peptidase-4, making it a potential candidate for the development of treatments targeting blood sugar regulation and related conditions.
Used in Anti-Cancer Research:
2-(2-OXO-2-PHENYLETHYL)BENZOIC ACID is used in anti-cancer research for its potential anti-cancer properties, with studies exploring its effectiveness in combating various types of cancer.
Used in Anti-Inflammatory Research:
2-(2-OXO-2-PHENYLETHYL)BENZOIC ACID is used in anti-inflammatory research for its potential to alleviate inflammation, offering a promising avenue for the development of treatments for inflammatory conditions.

InChI:InChI=1/C15H12O3/c16-14(11-6-2-1-3-7-11)10-12-8-4-5-9-13(12)15(17)18/h1-9H,10H2,(H,17,18)

Upstream product

• 528-46-1 phthalonic acid 
• 89-51-0 Homophthalic acid 
• 5955-73-7 2-methylbenzoyl cyanide 
• 613-90-1 benzoyl cyanide 
• 16619-12-8 2-phenyl-indan-1-one 
• 78317-99-4 (+/-)-cis-4-bromo-3-phenyl-isochroman-1-one 
• 100954-88-9 (+/-)-cis-4-chloro-3-phenyl-isochroman-1-one 
• 7446-70-0 aluminium trichloride 
• 703-59-3 homophthalic anhydride 
• 71-43-2 benzene 
• 7732-18-5 water 
• 29539-18-2 (+/-)-3-phenylisochroman 
• 22129-49-3 methyl 2-(2-oxo-2-phenylethyl) benzoate 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 4809-08-9 3-phenyl-isocoumarin 
• 230308-58-4 2-(1-diazo-2-oxo-2-phenyl-ethyl)-benzoic acid methyl ester 
• 35968-90-2 1,2-dihydro-4-phenyl-5H-benzo2,3-diazepin-1-one 
• 60159-71-9 2,10a-diphenyl-2,3,10,10a-tetrahydro-oxazolo[3,2-b]isoquinolin-5-one 
• 19169-86-9 Methyl-(2-phenacyl-benzoyl)carbonat 

Relevant academic research and scientific papers

Ruthenium(IV) Intermediates in C?H Activation/Annulation by Weak O-Coordination

Ruthenium(IV) complexes were identified as key intermediates of C?H/O?H activations by weak O-coordination. Thus, the annulations of sulfoxonium ylides by benzoic acids provided expedient access to diversely-decorated isocoumarins with ample scope. Detailed experimental and computational studies provided strong support for a facile BIES-C?H activation, along with cyclometalated ruthenium(IV) intermediates within a versatile ruthenium(II/IV) catalysis regime (BIES=base-assisted internal electrophilic substitution).

Oxidation of 3-arylisochromans by dimethyldioxirane. An easy route to substituted 3-arylisocoumarins

The selective oxidation of the two different benzylethereal position of 3-arylisochromans by dimethyldioxirane as a function of different substituents on the aromatic rings was studied. The easy oxidation of these compounds was exploited for a new easy ac

Reactions of carbonyl compounds in basic solutions. Part 21. The mechanisms of the alkaline hydrolysis of substituted methyl 2-(2-oxopropyl)- and 2-(2-oxo-2-phenylethyl)-benzoates and 2-(2-acetylphenyl)- and 2-(2-benzoylphenyl)-acetates

Rate coefficients have been measured for the alkaline hydrolysis of methyl 2-[2-oxo-2-(3- or 4-substituted phenyl)ethyl]benzoates, 2-[2-(3- or 4-substituted benzoyl)phenyl]acetates,2-(2-oxopropyl) and 2-(1,1-dimethyl-2- oxopropyl)benzoates, 2-(2-acetylphenyl)acetate and 2-(2-acetylphenyl)-2,2- dimethylacetates in 70% (v/v) dioxane-water at 30.0 °C. Those for the six parent esters were also measured at 45.0 and 60.0 °C and the enthalpies and entropies of activation have been evaluated. The relative rates of hydrolysis, activation parameters and substituent effects have been used to demonstrate neighbouring participation by the keto-carbonyl groups in the alkaline hydrolysis of the esters under study. For comparable systems, participation by six-membered ring intermediates appears somewhat less advantageous than five-membered.

The preparation of 2-(2-oxo-2-phenylethyl)benzoic acids from dilithiated ortho-toluic acid

Ortho-Toluic acid was dimetalated with excess lithium diisopropylamide, and the resulting intermediate was condensed with a variety of aromatic esters to afford new substituted 2-(2-oxo-2-phenylethyl)benzoic acids (ortho-phenacylbenzoic acids).

Acyl Cyanides as Carbonyl Heterodienophiles

Acyl cyanides have been shown to behave as carbonyl dienophiles in reactions with electron-rich o-quinodimethanes.This represents the first observation of an acyl cyanide carbonyl group reacting in such a manner.