288102-65-8

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 288102-57-8 (1S,2S,4S,5R,10R/S)-2-(benzoyloxymethyl)-5-(10-bromoethyl)-1-azabicyclo[2.2.2]octane 
• 288102-44-3 (1S,2S,4S,5R,10R/S)-2-hydroxymethyl-5-(10-bromoethyl)-1-azabicyclo[2.2.2]octane 
• 288102-46-5 (1S,2S,4S)-2-hydroxymethyl-(E/Z)-5-ethylidene-1-azabicyclo[2.2.2]octane 
• 288102-63-6 (1S,2S,4S)-2-(tert-butyldiphenylsilyloxymethyl)-(E/Z)-5-ethylidene-1-azabicyclo[2.2.2]octane 

Downstream Products

• 288102-68-1 (1S,2S,4S)-2-(tert-butyldiphenylsilyloxymethyl)-1-azabicyclo[2.2.2]octan-5-one 

Relevant academic research and scientific papers

Synthesis of enantiopure 3-quinuclidinone analogues with three stereogenic centers: (1S,2R,4S)- and (1S,2S,4S)-2-(hydroxymethyl)-1-azabicyclo[2.2.2]octan-5-one and stereocontrol of nucleophilic addition to the carbonyl group

The pseudoenantiomeric title compounds have been prepared from quincorine (QCI) and quincoridine (QCD), respectively, in enantiopure form following an efficient six-step pathway. Nucleophilic attack at the carbonyl group proceeds preferentially from the s