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Surinabant is a potent and selective antagonist for the cannabinoid-1 receptor, which is crucial in regulating appetite and body weight. Initially developed as a potential treatment for obesity and related metabolic disorders, it works by blocking the cannabinoid system that promotes hunger and increases energy storage. However, due to concerns over potential psychiatric side effects such as depression and anxiety, the clinical development of surinabant was discontinued, despite its promising initial effects on weight loss and metabolic improvements.
Usage:
Used in Pharmaceutical Development:
Surinabant was developed as a potential treatment for obesity and related metabolic disorders.
It is used as a cannabinoid-1 receptor antagonist for blocking the action of the cannabinoid system, which is responsible for promoting hunger and increasing energy storage.
Used in Clinical Trials:
Surinabant was used in clinical trials to evaluate its efficacy in weight loss and improvements in metabolic parameters.
However, due to the safety profile concerns, including potential psychiatric side effects such as depression and anxiety, its development was discontinued in clinical trials and further development stages.

288104-79-0

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288104-79-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 288104-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,1,0 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 288104-79:
(8*2)+(7*8)+(6*8)+(5*1)+(4*0)+(3*4)+(2*7)+(1*9)=160
160 % 10 = 0
So 288104-79-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31)

288104-79-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-piperidin-1-ylpyrazole-3-carboxamide

1.2 Other means of identification

Product number -
Other names Surinabant

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:288104-79-0 SDS

288104-79-0Downstream Products

288104-79-0Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF PYRAZOLE DERIVATIVES

-

, (2008/12/08)

A process for preparation of Pyrazole derivatives adapted for one pot reaction involving the use of a pyclizing agent and involving the step of amidation in the presence of a catalyst. The steps for isolation and purification of found Pyrazole derivatives are also disclosed.

Pyrazolecarboxylic acid derivatives, their preparation, pharmaceutical compositions containing them

-

, (2008/06/13)

N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide and its salts and solvates are powerful antagonists of the CB1cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-

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