288148-77-6Relevant academic research and scientific papers
Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules
Wang, Wuyi,Preville, Patrice,Morin, Nicolas,Mounir, Samir,Cai, Weizhong,Siddiqui, M. Arshad
, p. 1151 - 1154 (2007/10/03)
An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency. (C) 2000 Elsevier Science Ltd. All rights reserved.
