288151-49-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-6-fluoro-2-methylquinoline serves as a valuable intermediate for the synthesis of other organic compounds, playing a crucial role in the development of new drugs. Its distinctive chemical structure contributes to its potential applications in creating innovative pharmaceuticals.
Used in Medicinal Chemistry Research:
4-AMINO-6-FLUORO-2-METHYLQUINOLINE is utilized in the study and treatment of various diseases, such as malaria and cancer. The exploration of 4-amino-6-fluoro-2-methylquinoline's potential in medicinal chemistry is ongoing, with the aim of discovering its full therapeutic capabilities and enhancing its utility in healthcare.

InChI:InChI=1/C10H9FN2/c1-6-4-9(12)8-5-7(11)2-3-10(8)13-6/h2-5H,1H3,(H2,12,13)

Upstream product

• 49612-15-9 1-(6-fluoro-2-methylquinolin-4-yl)hydrazine 

Relevant academic research and scientific papers

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors.

Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists

The present invention provides phenyl urea and phenyl thiourea derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors, of formula (I) in which: Z represents oxygen or sulfur; and R1to R7represent various substituent groups; and pharmaceutically acceptable salts thereof. In particular, these compounds are of potential use in the treatment of obesity including obesity observed in Type 2(non-insulin-dependent) diabetes patients and/or sleep disorders.