28824-91-1

Usage

Chemical class

Ketone derivative

Structural features

Imidazole ring
Phenyl group
Methyl group

Applications

Organic synthesis
Pharmaceutical research

Potential biological activities

Unknown, but likely due to its structure and properties

Suitability

For the development of new drugs and biologically active molecules

Pharmacological effects

Range of potential effects, depending on its specific interactions with biological targets

Importance

As a building block in the development of new chemical entities for various medicinal applications

Upstream product

• 102826-92-6 4-benzylimino-pentane-2,3-dione-3-oxime 
• 29917-12-2 Isonitrosoacetylacetone 
• 81447-35-0 2,4-dioxopentan-3-yl 4-methylbenzenesulfonate 
• 618-39-3 benzamidin 
• 123-54-6 acetylacetone 
• 100-46-9 benzylamine 

Downstream Products

• 1297309-96-6 2-cyano-N'-[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]acetohydrazide 
• 1297309-74-0 2-(1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene)hydrazinecarbothioamide 
• 1297309-82-0 4-methyl-2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}-5-(2-phenylhydrazono)-2,5-dihydrothiazole 
• 1297309-84-2 5-[2-(4-chlorophenyl)hydrazono]-4-methyl-2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}-2,5-dihydrothiazole 
• 1297309-86-4 2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}-2,9a-dihydrothiazolo[5,4-b]quinoxaline 
• 1297309-88-6 2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}thiazolidin-4-one 
• 1297309-90-0 5-(4-fluorobenzylidene)-2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}thiazolidin-4-one 
• 1297309-92-2 2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}-5-((1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene)thiazolidin-4-one 
• 1297309-94-4 5-{[3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}thiazolidin-4-one 
• 1297309-98-8 2-cyano-3-(4-fluorophenyl)-N'-[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]acrylohydrazide 
• 1297310-00-9 2-cyano-N'-[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]-3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]acrylohydrazide 
• 1297310-02-1 3-[3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl]-2-cyano-N'-[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]acrylohydrazide 
• 1297310-03-2 7-hydroxy-2-imino-N'-[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]-2H-chromene-3-carbohydrazide 
• 1297309-76-2 2-{[1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene]hydrazono}-4-phenyl-2,5-dihydrothiazole 

Relevant academic research and scientific papers

Hypervalent iodine in synthesis 81: A one-pot procedure for the synthesis of 1H-imidazole derivatives by cyclocondensation of ketones with [Hydroxy(tosyloxy)iodo]benzene and amidines

Tosyloxylation of ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB), followed by treatment with amidines provides a one-pot procedure for the synthesis of 1H-imidazole derivatives with good yields.

Syntheses of 2-Arylimidazole Derivatives through Annelations Employing Benzylamines

Annelations of benzylamines with hydroximino derivatives of pentane-2,4-dione or of alkyl acetoacetates, acetoacetamides, and acetoacetanilides, afford imidazole derivatives and provide easy incorporation of the benzylic carbon and nitrogen in the heterocycle.The limits of the reaction have been explored.

IMIDAZO [1,5-d]-AS-TRIAZINE-4(3H)-ONES AND THIONES

There is provided substituted imidazo[1,5-d]-as-triazine-4(3H)-ones and substituted imidazo[1,5-d]-as-triazin-4(3H)-thiones useful as inhibitors of the enzyme cyclic-AMP phosphodiesterase and as broad spectrum herbicides