288256-68-8Relevant academic research and scientific papers
Steroids from herbs of Reineckia carnea and their anticomplement activities
Xu, Xu,Wu, Bei,Zhan, Yanzhi,Huang, Wenping,Yang, Shilin,Wen, Quan,Feng, Yulin
, p. 1 - 7 (2018)
A new polyhydroxylated pregnane, named lβ,2β,3β,4β,5β,6β-hexolhydroxy-pregn-16-en-20-one (1), along with nine known (2–10) steroidal saponins were isolated from the whole plant of Reineckia carnea.?Structure elucidations?of all compounds were established by interpretation of their NMR spectral data, HR-ESI-MS and comparing with literatures. In addition, these compounds were evaluated with anticomplement activity. The result showed that compound 1 exhibited anticomplement effects with the CH50 values of 0.043?mg/mL, but saponins (2–10) showed no inhibition. Interestingly, hydrolysis of steroidal saponins (2–10) resulted in its aglycones (2a–10a) correspondingly which showed anticomplement activity with the CH50 values of 0.049–0.156?mg/mL.
