288267-00-5

Upstream product

• 1450994-70-3 (3-bromo-2H-chromen-7-yloxy)(tert-butyl)dimethylsilane 
• 151884-07-0 2',4'-dihydroxy-3-chloropropiophenone 
• 124887-46-3 3-bromo-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one 
• 76240-27-2 7-hydroxy-2,3-dihydro-4H-chromen-4-one 
• 108-46-3 recorcinol 
• 1096622-31-9 3',7-diacetoxy-2-methyl-isoflav-3-ene 
• 288266-90-0 3',7-diacetoxy-isoflav-3-ene 

Downstream Products

• 1055327-38-2 3-(3-phenyl-2,3,4,8-tetrahydrochromeno[6,7-e][1,3]oxazin-7-yl)phenol 
• 1055327-37-1 3-(3-benzyl-2,3,4,8-tetrahydrochromeno[6,7-e][1,3]oxazin-7-yl)phenol 
• 1055327-47-3 3-(3-p-tolyl-2,3,4,8-tetrahydrochromeno[6,7-e][1,3]oxazin-7-yl)phenol 
• 1055327-48-4 4-(7-(3-hydroxyphenyl)chromeno[6,7-e][1,3]oxazin-3(2H,4H,8H)-yl)benzonitrile 
• 1055327-44-0 3-(3-(3-methoxypropyl)-2,3,4,8-tetrahydrochromeno[6,7-e][1,3]oxazin-7-yl)phenol 

Relevant academic research and scientific papers

Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist

Total synthesis of eryvarin H and a biological investigation of its analogues as a potential inverse agonist of ERRγ are described here. Among the 13 analogues prepared by the modular synthetic route, eryvarin H and compound 12 showed meaningful ERRγ inverse agonistic activities along with moderate selectivity over ERα and other nuclear receptors in the cell-based reporter gene assay.

2-SUBSTITUTED ISOFLAVONOID COMPOUNDS, MEDICAMENTS AND USES

2-Substituted isoflavonoid compounds and pharmaceutical compositions containing same are useful as anti-inflammatory agents and antioxidants and for the treatment of related diseases and conditions.

Production of isoflavone derivatives

Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.