288323-41-1 Usage
Biological Activity
thienyldecyl isothiocyanate is a cytochrome p450 inhibitor [1].the human cytochrome p450 (cyp), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin d3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. until now, there are more than 270 different cyp gene families have been identified, with 18 recorded in mammals. it has been repoted that cytochrome p450 is now understood to include a myriad of enzymic reactions implicated in important life processes. mutations in many cyp genes result in inborn errors of metabolism and contribute to many clinically relevant diseases [2].thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome p450, and/or by induction of phase ii detoxifying enzymes [1].
references
[1] yu r, mandlekar s, harvey k j, et al. chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity[j]. cancer research, 1998, 58(3): 402-408.[2] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
Check Digit Verification of cas no
The CAS Registry Mumber 288323-41-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,3,2 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 288323-41:
(8*2)+(7*8)+(6*8)+(5*3)+(4*2)+(3*3)+(2*4)+(1*1)=161
161 % 10 = 1
So 288323-41-1 is a valid CAS Registry Number.
288323-41-1Relevant academic research and scientific papers
Heterocyclic compounds for cancer chemoprevention
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, (2008/06/13)
A compound comprising a heterocyclic moiety, such as a thiophene, covalently attached to an alkylene isothiocyanate moiety. The compound is effective to prevent the occurrence or progression of cancer or a precancerous condition, and can be used for therapeutic or prophylactic purposes. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.
