288371-85-7

Upstream product

• 26972-56-5 2-(phenylamino)acetaldehyde dimethyl acetal 

Downstream Products

• 404933-73-9 N-methoxycarbonyl-N-phenylaminoacetaldehyde phenylhydrazone 
• 288371-91-5 3-[(methoxy)methoxy]-1-phenyl-4-[2-(trimethylsilyl)ethynyl]-2-imidazolidinone 
• 288371-94-8 4-ethynyl-3-hydroxy-1-phenyl-2-imidazolidinone 

Relevant academic research and scientific papers

Pyridazinones and triazinones and medicinal use thereof

The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, A1, A2 and A3 are independent of each other and each represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may be substituted; Q represents O, S or NH; Z represents C or N; X1, X2 and X3 are independent of each other and each represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —NH—, —O—, —NHCO—, —CONH—, —SO0-2, etc.; R1 and R2 are independent of each other and each represents a hydrogen atom or an optionally substituted C1-6 alkyl group, or R1 and R2 may be bound together such that CR2-ZR1 forms C═C; and R3 represents a hydrogen atom or an optionally substituted C1-6 alkyl group etc., or may be bound to any atom in A1 or A3 to form, together with the atom, an optionally substituted C5-8 hydrocarbon ring or an optionally substituted 5- to 8-membered heterocyclic ring.

A new route to 4-ethynyl-N-hydroxy-2-imidazolidinones via oxime addition

A rapid route was developed to afford ethynyl-substituted imidazole derivatives which served as key compounds for arylalkynyl-coupling reactions. Addition of mono-silylated acetylene to O-protected oximes was carried out in the absence of Lewis acids, directly affording the title compounds 3a-c in a one-pot reaction. Limitations and dependence of the feasibility on N1- substituents are discussed. (C) 2000 Elsevier Science Ltd.