288374-75-4

Upstream product

• 5927-18-4 trimethyl phosphonoacetate 
• 288374-69-6 (3R,4S,6R)-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexanal 
• 20698-91-3 (R)-methyl mandelate 
• 288374-65-2 (R)-(-)-N-methyl-N-methoxy(2-hydroxy-2-phenyl)acetamide 
• 288374-67-4 (R)-(+)-(1-tert-butyldimethylsilyloxy-1-phenyl)butan-2-one 
• 288374-66-3 (R)-(-)-N-methyl-N-methoxy(2-tert-butyldimethylsilyloxy-2-phenyl)acetamide 
• 288374-68-5 (3R,4S,6R)-1,1-diethoxy-3-hydroxy-4-methyl-5-oxo-6-[(tert-butyl-dimethylsilyl)oxy]-6-phenylhexane 

Downstream Products

• 288374-80-1 methyl (5R,6S,8R)-5-tosyloxy-6-methyl-7-oxo-8-[(tert-butyl-dimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate 
• 288374-78-7 methyl (5R,6S,7R,8R)-5,7-dihydroxy-6-methyl-8-[(tert-butyldimethylsilyl)oxy]-8-phenyloct-2(E)-enoate 
• 288374-81-2 methyl (5R,6R,7R,8R)-5-tosyloxy-6-methyl-7-hydroxy-8-[(tert-butyl-dimethylsilyl)oxy]-8-phenyl-oct-2(E)-enoate 

Relevant academic research and scientific papers

Synthesis of 1-aza-cryptophycin 1, an unstable cryptophycin. An unusual skeletal rearrangement

A total synthesis of cryptophycin 337 (1-aza-cryptophycin 1, 2), an analogue of the potent antitumor antibiotic cryptophycin 1 (1), is described. Cryptophycin 337 was unstable and underwent an unexpected skeletal rearrangement. (R)-Mandelic acid was used as the sole source of asymmetry for the synthesis of unit A. (C) 2000 Elsevier Science Ltd.