288380-86-9

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 288380-84-7 (3S,4R)-4-(tert-butyldimethylsilanyloxy)-3-[(R)-1-(tert-butyldimethylsilanyloxy)allyl]hept-6-yn-1-ol 
• 288380-79-0 (3R,4S,5R)-4-(tert-butyldimethylsilanyloxymethyl)-3-(methoxymethoxy)-5,6-epoxyhex-1-ene 
• 288380-77-8 benzyl 5-O-pivaloyl-2-O-methoxymethyl-3-deoxy-3-C-(tert-butyldimethylsilyloxymethyl)-α-D-lyxo-pentofuranose 
• 288380-81-4 1-pivalic acid (2S,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(R)-1-(tert-butyldimethylsilanyloxy)allyl]hex-5-ynyl ester 
• 288380-97-2 (3S,4R)-4-(tert-butyldimethylsilanyloxy)-3-[(R)-1-(tert-butyldimethylsilanyloxy)allyl]hept-6-ynnitrile 
• 288380-98-3 (3S,4R)-4-(tert-butyldimethylsilanyloxy)-3-[(R)-1-(tert-butyldimethylsilanyloxy)allyl]hept-6-ynal 
• 288380-80-3 (4R,5S,6R)-5-(tert-butyldimethylsilanyloxymethyl)-6-(methoxymethoxy)-1-(trimethylsilanyl)-oct-7-en-1-yn-4-ol 
• 288380-82-5 (2S,3S)-3-(tert-butyldimethylsilanyloxy)-2-[(R)-1-(tert-butyldimethylsilanyloxy)allyl]hex-5-yn-1-ol 
• 288380-78-9 (2R,3R,4R)-1-pivalic acid 3-(tert-butyldimethylsilanyloxymethyl)-2-hydroxy-4-methoxymethoxyhex-5-enyl ester 
• 288380-76-7 benzyl 5-O-pivaloyl-2-O-methoxymethyl-3-deoxy-3-C-hydroxymethyl-α-D-lyxo-pentofuranose 
• 288380-92-7 benzyl 3-deoxy-3-C-methylene-2-O-methoxymethyl-5-O-pivaloyl-α-D-lyxo-pentofuranoside 
• 288380-75-6 benzyl 3-deoxy-3-C-methylene-5-O-pivaloyl-α-D-lyxo-pentofuranoside 
• 288380-74-5 benzyl 3-deoxy-3-C-methylene-5-O-pivaloyl-α-D-xylopentofuranoside 

Relevant academic research and scientific papers

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues with 2α-alkyl and 2α-hydroxyalkyl groups were systematically synthesized from D-xylose. Their conformation on binding to the ligand binding domain (LBD) of the vitamin D receptor was analyzed. It has been found that the 2α-hydroxypropyl group best fits the cavity of the LBD, and the binding activity is three times higher than that for the natural hormone.

Syntheses and biological evaluation of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues

Novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues were efficiently synthesized and their biological activities were evaluated. 2α-Methyl-1α25-dihydroxyvitamin D3 (2), whose unique biological activities were previously reported