28845-75-2

Basic information

• Product Name: 2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester
• Synonyms: 2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester;Ethyl 2,2-dibromodiethylphosphonoacetate;Triethyl 2,2-dibromophosphonoacetate
• CAS NO: 28845-75-2
• Molecular Formula: C₈H₁₅Br₂O₅P
• Molecular Weight: 381.983461
• Mol File: 28845-75-2.mol
• Article Data: 4

Chemical Properties

• Flash Point: >110℃
• Appearance: /
• Density: 1.636 at 25 °C
• Refractive Index: n20/D1.493
• CAS DataBase Reference: 2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester(28845-75-2)
• EPA Substance Registry System: 2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester(28845-75-2)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2810 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 28845-75-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 28845-75-2 differently. You can refer to the following data:
1. Ethyl 2,2-Dibromodiethylphosphonoacetate acts as a reagent in the synthesis of dialkylphosphonodibromoacetates and dialkylphosphonodibromoacetonitriles as potential new biocides.
2. Coupling partner in Suzuki-Miyuara C-C bond formations

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 123098-25-9 ethyl 2-bromo-3-(4-methoxyphenyl)-2(E)-propenoate 
• 123098-26-0 ethyl 2-bromo-3-(4-methoxyphenyl)-2(Z)-propenoate 
• 23755-73-9 triethyl bromophosphonoacetate 

Relevant articles and documents

Visible-Light-Promoted Generation of α-Ketoradicals from Vinyl-bromides and Molecular Oxygen: Synthesis of Indenones and Dihydroindeno[1,2-c]chromenes

Ortho-alkynylated α-bromocinnamates can be converted by a visible-light-mediated photocascade reaction with molecular oxygen into either indenones or dihydroindeno[1,2-c]chromenes. The one-step process features key photochemical steps, that is, the initial activation of vinyl bromides through energy transfer to give α-ketoradicals in a reaction with molecular oxygen, followed by α-oxidation of an arene moiety by 6-π electrocyclization, and subsequent hydroxylation by an electron-transfer process from the same photocatalyst leads to the dihydroindeno[1,2-c]chromenes.

A new general approach to 4-substituted-3-halo-2-quinolones

A general procedure for the preparation of 4-substituted-3-halo-2-quinolones (halo = F, Cl, Br) utilizing 2-halo diethylphosphonoacetic acids (halo = F, Cl, Br) and o-aminophenylketones as the starting materials is described. The title compounds are obtained by an intramolecular Horner-Wadsworth-Emmons olefination of halogen-containing N-acyl-o-aminophenylketones. The transformation process is generally applicable under mild conditions.