28845-75-2

Usage

Uses

Used in Chemical Synthesis:
2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester is used as a reagent for the synthesis of dialkylphosphonodibromoacetates and dialkylphosphonodibromoacetonitriles. These compounds are considered potential new biocides, which can be utilized in various industries for their antimicrobial and antifouling properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2-Dibromo-2-(diethoxyphosphinyl)acetic acid ethyl ester serves as a coupling partner in Suzuki-Miyuara C-C bond formations. This reaction is a widely used method for the formation of carbon-carbon bonds, which is crucial in the synthesis of complex organic molecules, including potential drug candidates.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 123098-25-9 ethyl 2-bromo-3-(4-methoxyphenyl)-2(E)-propenoate 
• 123098-26-0 ethyl 2-bromo-3-(4-methoxyphenyl)-2(Z)-propenoate 
• 23755-73-9 triethyl bromophosphonoacetate 

Relevant academic research and scientific papers

Visible-Light-Promoted Generation of α-Ketoradicals from Vinyl-bromides and Molecular Oxygen: Synthesis of Indenones and Dihydroindeno[1,2-c]chromenes

Ortho-alkynylated α-bromocinnamates can be converted by a visible-light-mediated photocascade reaction with molecular oxygen into either indenones or dihydroindeno[1,2-c]chromenes. The one-step process features key photochemical steps, that is, the initial activation of vinyl bromides through energy transfer to give α-ketoradicals in a reaction with molecular oxygen, followed by α-oxidation of an arene moiety by 6-π electrocyclization, and subsequent hydroxylation by an electron-transfer process from the same photocatalyst leads to the dihydroindeno[1,2-c]chromenes.

Enantioselective organocatalytic synthesis of α- cyclopropylphosphonates through a domino michael addition/intramolecular alkylation reaction

An organocatalytic domino reaction consisting of Michael addition/intramolecular alkylation between α,β-unsaturated aldehydes and bromophosphonoacetates was developed. Highly functionalised cyclopropylphosphonates containing three chiral centres, one of them quaternary, were obtained with good diastereoselectivities of up to 83:17 and very high enantioselectivities of up to 99 %. α-Cyclopropylphosphonates with three stereogenic centres were obtained in good yields and high enantio-and diastereocontrol through a "one-pot" domino process catalysed by a chiral pyrrolidine. The highly functionalised cyclopropanes should be versatile starting materials for biologically important compounds. Copyright

A new general approach to 4-substituted-3-halo-2-quinolones

A general procedure for the preparation of 4-substituted-3-halo-2-quinolones (halo = F, Cl, Br) utilizing 2-halo diethylphosphonoacetic acids (halo = F, Cl, Br) and o-aminophenylketones as the starting materials is described. The title compounds are obtained by an intramolecular Horner-Wadsworth-Emmons olefination of halogen-containing N-acyl-o-aminophenylketones. The transformation process is generally applicable under mild conditions.