288458-59-3

Basic information

• Product Name: 1H-Indole,4,6-diethyl-2,3-dihydro-(9CI)
• Synonyms: 1H-Indole,4,6-diethyl-2,3-dihydro-(9CI)
• CAS NO: 288458-59-3
• Molecular Formula: C12H17N
• Molecular Weight: 175.27008
• Product Categories: CYCLOHEXANE
• Mol File: 288458-59-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole,4,6-diethyl-2,3-dihydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole,4,6-diethyl-2,3-dihydro-(9CI)(288458-59-3)
• EPA Substance Registry System: 1H-Indole,4,6-diethyl-2,3-dihydro-(9CI)(288458-59-3)

Safety Data

• Hazardous Substances Data: 288458-59-3(Hazardous Substances Data)

Usage

Molecular Structure

A derivative of indole consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring.

Substitution

Two ethyl groups at positions 4 and 6 on the indole ring.

Aromatic

The compound has an aromatic character due to the presence of the benzene ring.

Heterocyclic

The compound contains a pyrrole ring, which is a nitrogen-containing five-membered ring.

Potential Applications

The compound has potential uses in pharmaceuticals and agrochemicals.

Unique Chemical Structure

The presence of ethyl groups at positions 4 and 6 distinguishes this compound from other indole derivatives.

Reactivity

The compound exhibits unique chemical reactivity due to its structure.

Scientific and Industrial Interest

The properties and potential uses of 1H-Indole,4,6-diethyl-2,3-dihydro-(9CI) make it a subject of interest for further study and development in various scientific and industrial fields.

Relevant articles and documents

Bioavailable acyl-CoA : Cholesterol acyltransferase inhibitor with anti- peroxidative activity: Synthesis and biological activity of novel indolinyl amide and urea derivatives

We synthesized a series of indoline derivatives with an amide or urea moiety and examined their inhibitory effects on acyl-CoA : cholesterol acyltransferase (ACAT) activity, lipid-peroxidation and serum cholesterol levels in experimental animals. Among the derivatives synthesized, a series of N-(1-alkyl-4,6- dimethylindolin-7-yl)-2,2-dimethylpropanamides potently inhibited rabbit intestinal ACAT activity and lipid-peroxidation of rat brain homogenate. The effect on ACAT activity was related to the length of the alkyl chain at the 1-position of indoline. N-(4,b-Dimethyl-1-octylindolin-7- yl)-2,2-dimethylpropanamide hydrochloride (55) showed inhibitory effects on intestinal and hepatic ACAT activity slightly weaker than those of YM-750, and an inhibitory effect on low density lipoprotein (LDL)-peroxidation similar to that of probucol. Compound 55 also reduced serum cholesterol at 10 mg/kg/d in hyperlipidemic rats and 20 mg/kg/d in normolipidemic hamsters. The plasma concentration of 55 reached 716 ng/ml in dogs (10 mg/kg, p.o.), which is an effective concentration against hepatic ACAT activity and LDL- peroxidation. In conclusion, compound 55 is a novel bioavailable ACAT inhibitor with anti-peroxidative activity and is thus a promising anti- atherosclerotic and anti-hyperlipidemic drug. Indoline proved to be a useful pharmacophore for molecular design of new anti-peroxidative drugs.