288571-53-9Relevant academic research and scientific papers
Antimalarial sulfide, sulfone, and sulfonamide trioxanes
Posner, Gary H.,Maxwell, John P.,O'Dowd, Hardwin,Krasavin, Mikhail,Xie, Suji,Shapiro, Theresa A.
, p. 1361 - 1370 (2000)
A series of trioxanes featuring sulfide, sulfone, and sulfonamide substituents in diverse positions has been prepared. Structure-activity relationship (SAR) generalizations highlight two major factors controlling the antimalarial potency of these new chemical entities: (1) the proximity of the sulfur-containing substituent to the crucial peroxide bond and (2) the oxidation state of the sulfur-containing substituent. Generally, sulfones are more antimalarially potent than the corresponding sulfides. Copyright (C) 2000 Elsevier Science Ltd.
