288585-97-7Relevant academic research and scientific papers
Synthesis and GC-EIMS analyses of optically pure 3-hydroxy-2- azetidinones having N-sulfonamide drugs side chain
Hassan, Hammed H. A. M.,Soliman, Raafat
, p. 2465 - 2478 (2007/10/03)
A series of new N-sulfonamides of substituted 3-hydroxy-2-azetidinones were prepared by the [2+2] cycloaddition of aldoximes, formed from the condensation of D-(R)-glyceraldehyde acetonide and the potent p-aminophenyl- N-substituted sulfonamides, with benzyloxyacetyl chloride followed by removal of the protecting groups. Obtaining both diastereoisomeric forms of β- lactams by resorting to kinetic resolution starting from racemic imino analogue is also described. The GC-EIMS, spectroscopic and analytical analyses for some of these derivatives are reported.
