288586-95-8

Upstream product

• 5911-08-0 chloro(cyclopropyl)methane 
• 70768-88-6 5,6-bis(4-Methoxyphenyl)-4-ethoxy-carbonyl-2H-pyridazin-3-one 

Downstream Products

• 288586-96-9 5,6-bis(4-methoxyphenyl)-4-carboxy-2-cyclopropylmethyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Pyridazin-3-one derivatives and medicines containing the same

Objects of the invention are to provide compounds having excellent activity against interleukin-1β production and also medicines comprising them as effective ingredients. Pyridazin-3-one derivatives represented by the following formula (1): wherein Arsup

PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME

Objects of the invention are to provide compounds having excellent activity against interleukin-1β production and also medicines comprising them as effective ingredients. Pyridazin-3-one derivatives represented by the following formula (1): wherein Ar1 represents a substituted or unsubstituted aromatic group, Ar2 represents a phenyl group having a substituent at least at the 4-position thereof, R1 represents a linear or branched alkyl group, an alkyl group having a cyclic structure, a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenyl(lower alkyl) group, and R2 represents a cyano group, a carboxyl group, a (lower alkoxy)carbonyl group, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted carbamoyl group, or salts thereof; and medicines comprising them as effective ingredients.