288587-10-0Relevant articles and documents
CCSO nano catalyzed solid phase synthesis of 3-oxo-5,6-disubstituted-2,3-dihydropyridazine-4-carbonitrile
Singh, Praveen,Kumar, Ranjeet,Yadav, Brijesh Kumar,Khanna, Ranjana S.,Tewari, Ashish Kumar
, p. 51239 - 51243 (2014)
Co-doped Ce0.94Ca0.05Sr0.01O1.94 (CCSO) nano particles have been successfully synthesized by an auto-combustion method and were characterized by XRD, TEM and AFM analyses. The catalytic activity of the nano-catalyst is evaluated by the synthesis of substituted pyridazines from substituted benzil and cyano acetylhydrazide, which have great biological and pharmaceutical interest. Thus, a highly economically efficient one-pot solvent free synthesis of pyridazine was developed, which is promoted by the CCSO nano catalyst. The benefits of the reaction are its very short time (2-4 min) and high yields (90-95%). The method offers a highly convergent, inexpensive, and functionality-tolerable procedure for rapid access to important pyridazine compounds in good yields. This journal is
Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases
Bra?a, Miguel F.,Cacho, Mónica,García, M. Luisa,Mayoral, Elena P.,López, Berta,De Pascual-Teresa, Beatriz,Ramos, Ana,Acero, Nuria,Llinares, Francisco,Mu?oz-Mingarro, Dolores,Lozach, Olivier,Meijer, Laurent
, p. 6843 - 6854 (2007/10/03)
Pyrazolopyridazine 1a was identified in a high-throughput screening carried out by BASF Bioresearch Corp. (Worcester, MA) as a potent inhibitor of CDK1/cyclin B and shown to have selectivity for the CDK family. Analogues of the lead compound have been syn