288591-93-5 Usage
Uses
Used in Pharmaceutical Industry:
5'-O-[N-[L-leucyl]-sulfamoyl]adenosine is used as an inhibitor for leucyl-tRNA synthetase (LRS) for its potent antibacterial properties. With an IC50 of 22.34 nM, it effectively inhibits the growth of bacteria, making it a valuable compound in the development of new antibiotics and treatments for bacterial infections.
Used in Microbiology Research:
In the field of microbiology, 5'-O-[N-[L-leucyl]-sulfamoyl]adenosine serves as a crucial tool for studying the mechanisms of bacterial growth and the role of leucyl-tRNA synthetase in protein synthesis. Its ability to inhibit LRS provides researchers with a means to investigate the effects of LRS inhibition on bacterial cell function and survival.
Check Digit Verification of cas no
The CAS Registry Mumber 288591-93-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,5,9 and 1 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 288591-93:
(8*2)+(7*8)+(6*8)+(5*5)+(4*9)+(3*1)+(2*9)+(1*3)=205
205 % 10 = 5
So 288591-93-5 is a valid CAS Registry Number.
288591-93-5Relevant academic research and scientific papers
Extended targeting potential and improved synthesis of Microcin C analogs as antibacterials
Vondenhoff, Gaston H.M.,Dubiley, Svetlana,Severinov, Konstantin,Lescrinier, Eveline,Rozenski, Jef,Van Aerschot, Arthur
, p. 5462 - 5467 (2011/10/13)
Microcin C (McC) (1) is a potent antibacterial compound produced by some Escherichia coli strains. McC functions through a Trojan-Horse mechanism: it is actively taken up inside a sensitive cell through the function of the YejABEF-transporter and then pro
