28860-10-8

Basic information

• Product Name: N-ISOPROPYL 3-NITROBENZENESULFONAMIDE
• Synonyms: N-ISOPROPYL 3-NITROBENZENESULFONAMIDE;Benzenesulfonamide, N-(1-methylethyl)-3-nitro-
• CAS NO: 28860-10-8
• Molecular Formula: C₉H₁₂N₂O₄S
• Molecular Weight: 244.27
• Product Categories: blocks;NitroCompounds;Sulfonamides
• Mol File: 28860-10-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 381.2°C at 760 mmHg
• Flash Point: 184.3°C
• Appearance: /
• Density: 1.318g/cm³
• Vapor Pressure: 5.17E-06mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: N-ISOPROPYL 3-NITROBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ISOPROPYL 3-NITROBENZENESULFONAMIDE(28860-10-8)
• EPA Substance Registry System: N-ISOPROPYL 3-NITROBENZENESULFONAMIDE(28860-10-8)

Safety Data

• Hazardous Substances Data: 28860-10-8(Hazardous Substances Data)

Usage

General Description

N-ISOPROPYL 3-NITROBENZENESULFONAMIDE is a chemical compound that is commonly used as a pharmaceutical intermediate and a building block in the synthesis of various organic compounds. It is derived from 3-nitrobenzenesulfonyl chloride and isopropylamine, and it is typically used in the production of pharmaceutical drugs, agrochemicals, and dyes. N-ISOPROPYL 3-NITROBENZENESULFONAMIDE is known for its strong nitro and benzene functionalities, which give it a wide range of chemical reactivity and applications. It is important to handle N-ISOPROPYL 3-NITROBENZENESULFONAMIDE with care, as it can be hazardous if not properly managed.

InChI:InChI=1/C9H12N2O4S/c1-7(2)10-16(14,15)9-5-3-4-8(6-9)11(12)13/h3-7,10H,1-2H3

Upstream product

• 75-31-0 isopropylamine 
• 121-51-7 3-nitrobenzenesulphonyl chloride 

Downstream Products

• 118837-66-4 3-amino-N-(methylethyl)benzenesulfonamide 
• 121-52-8 3-nitrophenylsulfonamide 

Relevant articles and documents

BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.