288620-84-8

Upstream product

• 185847-84-1 benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate 
• 501-53-1 benzyl chloroformate 
• 620-08-6 4-methoxypyridine 
• 288620-82-6 2-vinyl-2,3-dihydro-1H-pyridin-4-one 
• 288620-83-7 4-oxo-2-vinyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 

Downstream Products

• 288620-85-9 (S)-4-Oxo-piperidine-1,2-dicarboxylic acid dibenzyl ester 
• 288620-86-0 (2S,4R)-4-Hydroxy-piperidine-1,2-dicarboxylic acid dibenzyl ester 
• 1844-40-2 (2S,4R)-4-hydroxypiperidine-2-carboxylic acid 

Relevant academic research and scientific papers

Copper-catalyzed asymmetric 1,4-addition of alkenyl alanes to N-substituted-2-3-dehydro-4-piperidones

Readily available vinyl alanes are used in the Cu-catalyzed asymmetric conjugate addition reaction to N-substituted-2-3-dehydro-4-piperidones. The enhanced reactivity of recently developed and easily prepared phosphine amine ligands in combination with inexpensive Cu(II)naphtenate (CuNp) allows the introduction of a great variety of alkenyl, alkyl, and aryl aluminums in high enantioselectivity.

Asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid

An asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid was accomplished in eight steps and 31% overall yield. (C) 2000 Elsevier Science Ltd.