28872-28-8 Usage
Description
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 μM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.
Uses
Different sources of media describe the Uses of 28872-28-8 differently. You can refer to the following data:
1. 8(Z),10(E),12(Z)-Octadecatrienoic Acid, is a conjugated Linoleic Acid, a compound that has reported to exhibit anticarcinogenic activity. Also a potent antioxidant.
2. Jacaric Acid (10mg/mL in Ethanol) is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.
Check Digit Verification of cas no
The CAS Registry Mumber 28872-28-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,8,7 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 28872-28:
(7*2)+(6*8)+(5*8)+(4*7)+(3*2)+(2*2)+(1*8)=148
148 % 10 = 8
So 28872-28-8 is a valid CAS Registry Number.
